Studies of teratogenic effects of the dithiocarbamates maneb, mancozeb, and propineb
| Autor: | K. Sune Larsson, Claes Arnander, Eva Cekanova, Marianne Kjellberg |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Embryology
animal structures Health Toxicology and Mutagenesis Maneb chemistry.chemical_element Zinc Acetates Pharmacology Toxicology Mice chemistry.chemical_compound Pregnancy Thiocarbamates Oral administration Animals Mancozeb Chelation Dithiocarbamate Zineb chemistry.chemical_classification Abnormalities Drug-Induced Fetal Resorption Teratology Rats chemistry embryonic structures Female Developmental Biology |
| Zdroj: | Teratology. 14:171-183 |
| ISSN: | 1096-9926 0040-3709 |
| DOI: | 10.1002/tera.1420140208 |
| Popis: | Oral administration of high dosages of the dithiocarbamate pesticides maneb and mancozeb was teratogenic in rats but not in mice. The malformations, severe limb and craniofacial defects, were pronounced after maneb treatment but less so after mancozeb and propineb, zinc-containing compounds. The teratogenic effect of maneb was progressively reduced by simultaneously administering increasing amounts of zinc acetate. The mechanism of the teratogenic effect may involve the compounds being chelating agents, trapping zinc required for many important enzyme systems. |
| Databáze: | OpenAIRE |
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