Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial
| Autor: | Magdalena Minnion, Colin D. Kay, Bernadette O. Fernandez, Amy Jennings, Anne Marie Minihane, Peter J. Curtis, A. Margot Umpleby, Eric B. Rimm, Aedin Cassidy, Mia S. Meiss, Vera van der Velpen, Lindsey Berends, John F. Potter, Mark L. Evans, Martin Feelisch |
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| Přispěvatelé: | Evans, Mark [0000-0001-8122-8987], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Blueberry Plants Medicine (miscellaneous) Blood Pressure Type 2 diabetes Lipoprotein particle Prospective Studies Pulse wave velocity 2. Zero hunger Metabolic Syndrome education.field_of_study Nutrition and Dietetics Heart Middle Aged 3. Good health metabolic syndrome blueberry anthocyanins flavonoids cardiovascular disease risk anthocyanin-derived phenolic acid metabolites Original Research Communications Female medicine.medical_specialty Statin medicine.drug_class Population Pulse Wave Analysis Anthocyanin-Derived Phenolic Acid Metabolites Blueberry Anthocyanins 03 medical and health sciences Insulin resistance Double-Blind Method SDG 3 - Good Health and Well-being Internal medicine medicine Humans education Aged Flavonoids 030109 nutrition & dietetics business.industry Cholesterol HDL Cholesterol LDL Cardiovascular Disease Risk medicine.disease Editor's Choice Apolipoproteins 030104 developmental biology Endocrinology Fruit Arterial stiffness Insulin Resistance Metabolic syndrome business Biomarkers |
| Zdroj: | Curtis, P J, Van Der Velpen, V, Berends, L, Jennings, A, Feelisch, M, Umpleby, A M, Evans, M, Fernandez, B O, Meiss, M S, Minnion, M, Potter, J, Minihane, A M, Kay, C D, Rimm, E B & Cassidy, A 2019, ' Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial ', American Journal of Clinical Nutrition, vol. 109, no. 6, pp. 1535-1545 . https://doi.org/10.1093/ajcn/nqy380 The American Journal of Clinical Nutrition |
| Popis: | BACKGROUND: Anthocyanin-rich blueberry intake is associated with reduced type 2 diabetes and cardiovascular disease (CVD) risk in prospective studies, although long-term randomized controlled trials (RCTs) have not been conducted in at-risk populations.OBJECTIVE: In the longest-duration RCT to date, we examined the effect of 6-mo blueberry intake on insulin resistance and cardiometabolic function in metabolic syndrome.METHODS: A double-blind, parallel RCT (n = 115; age 63 ± 7 y; 68% male; body mass index 31.2 ± 3.0 kg/m2) was conducted, which fed 2 dietarily achievable blueberry intakes [equivalent to 1/2 and 1 cup/d (75/150 g)] compared with matched placebo. Insulin resistance was assessed via the homeostasis model assessment of insulin resistance (primary endpoint) and confirmed by [6-6-2H2]-glucose-labeled, 2-step hyperinsulinemic clamp (n = 20). Clinically relevant cardiometabolic endpoints [including flow-mediated dilatation, augmentation index, lipoprotein status (by nuclear magnetic resonance spectroscopy), and nitric oxide (NO)-related metabolite assay] and anthocyanin metabolism were assessed.RESULTS: A daily intake of 1 cup of blueberries improved endothelial function (flow-mediated dilatation: +1.45%; 95% CI: 0.83%, 2.1%; P = 0.003), systemic arterial stiffness (augmentation index: -2.24%; 95% CI: -3.97%, -0.61%; P = 0.04) and attenuated cyclic guanosine monophosphate concentrations. In statin nonusers (n = 71), elevated high-density lipoprotein cholesterol (+0.08 mmol/L; P = 0.03), high-density lipoprotein particle density (+0.48n, ×10-6; P = 0.002) and apolipoprotein A-I (+0.05 g/L; P = 0.01) concentrations were observed following the 1-cup/d intervention. Treatment compliance was 94.1% (wrapper returns) and total concentrations of anthocyanin-derived phenolic acid metabolites significantly increased, dose-dependently, in serum and 24-h urine (P < 0.01 and P < 0.001, respectively). Insulin resistance, pulse wave velocity, blood pressure, NO, and overall plasma thiol status were unaffected. Likewise, a half cup per day had no effect on any biomarkers.CONCLUSIONS: Despite insulin resistance remaining unchanged we show, to our knowledge, the first sustained improvements in vascular function, lipid status, and underlying NO bioactivity following 1 cup blueberries/d. With effect sizes predictive of 12-15% reductions in CVD risk, blueberries should be included in dietary strategies to reduce individual and population CVD risk. This study was registered at clinicaltrials.gov as NCT02035592. |
| Databáze: | OpenAIRE |
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