Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies
Autor: | Hsin-Hua Li, I-Yen Lee, Nu-Man Tsai, Wen-Chieh Liao, Ying-Jui Ho, Mei-Shiuan Shen, Jun-Cheng Weng, Te-Jen Lai, Chih-Li Lin, Ching-Sui Hung |
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Rok vydání: | 2018 |
Předmět: |
Male
0301 basic medicine Pathology Hippocampal formation Hippocampus 0302 clinical medicine Premovement neuronal activity Neurons medicine.diagnostic_test Ceftriaxone Brain Neurodegenerative Diseases General Medicine Magnetic Resonance Imaging Subthalamic nucleus Neuropsychology and Physiological Psychology Neurology embryonic structures Toxicity alpha-Synuclein Immunohistochemistry RC321-571 Research Article medicine.drug Lewy Body Disease China medicine.medical_specialty animal structures Article Subject Neurosciences. Biological psychiatry. Neuropsychiatry 03 medical and health sciences mental disorders medicine Animals Rats Wistar business.industry Dementia with Lewy bodies Magnetic resonance imaging medicine.disease Rats nervous system diseases Disease Models Animal 030104 developmental biology nervous system Dementia Lewy Bodies Neurology (clinical) business 030217 neurology & neurosurgery |
Zdroj: | Behavioural Neurology Behavioural Neurology, Vol 2018 (2018) |
ISSN: | 1875-8584 0953-4180 |
Popis: | Dementia with Lewy bodies (DLB) is characterized by neuronal deficits and α-synuclein inclusions in the brain. Ceftriaxone (CEF), a β-lactam antibiotic, has been suggested as a therapeutic agent in several neurodegenerative disorders for its abilities to counteract glutamate-mediated toxicity and to block α-synuclein polymerization. By using manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemistry, we measured the effects of CEF on neuronal activity and α-synuclein accumulation in the brain in a DLB rat model. The data showed that CEF corrected neuronal density and activity in the hippocampal CA1 area, suppressed hyperactivity in the subthalamic nucleus, and reduced α-synuclein accumulation, indicating that CEF is a potential agent in the treatment of DLB. |
Databáze: | OpenAIRE |
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