Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies

Autor: Hsin-Hua Li, I-Yen Lee, Nu-Man Tsai, Wen-Chieh Liao, Ying-Jui Ho, Mei-Shiuan Shen, Jun-Cheng Weng, Te-Jen Lai, Chih-Li Lin, Ching-Sui Hung
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Pathology
Hippocampal formation
Hippocampus
0302 clinical medicine
Premovement neuronal activity
Neurons
medicine.diagnostic_test
Ceftriaxone
Brain
Neurodegenerative Diseases
General Medicine
Magnetic Resonance Imaging
Subthalamic nucleus
Neuropsychology and Physiological Psychology
Neurology
embryonic structures
Toxicity
alpha-Synuclein
Immunohistochemistry
RC321-571
Research Article
medicine.drug
Lewy Body Disease
China
medicine.medical_specialty
animal structures
Article Subject
Neurosciences. Biological psychiatry. Neuropsychiatry
03 medical and health sciences
mental disorders
medicine
Animals
Rats
Wistar
business.industry
Dementia with Lewy bodies
Magnetic resonance imaging
medicine.disease
Rats
nervous system diseases
Disease Models
Animal
030104 developmental biology
nervous system
Dementia
Lewy Bodies
Neurology (clinical)
business
030217 neurology & neurosurgery
Zdroj: Behavioural Neurology
Behavioural Neurology, Vol 2018 (2018)
ISSN: 1875-8584
0953-4180
Popis: Dementia with Lewy bodies (DLB) is characterized by neuronal deficits and α-synuclein inclusions in the brain. Ceftriaxone (CEF), a β-lactam antibiotic, has been suggested as a therapeutic agent in several neurodegenerative disorders for its abilities to counteract glutamate-mediated toxicity and to block α-synuclein polymerization. By using manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemistry, we measured the effects of CEF on neuronal activity and α-synuclein accumulation in the brain in a DLB rat model. The data showed that CEF corrected neuronal density and activity in the hippocampal CA1 area, suppressed hyperactivity in the subthalamic nucleus, and reduced α-synuclein accumulation, indicating that CEF is a potential agent in the treatment of DLB.
Databáze: OpenAIRE
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