Immunohistochemical Detection of Estrogen Receptor in Invasive Human Breast Cancer: Correlation with Heat Shock Proteins, pS2 and Oncogene Products
| Autor: | Takayuki Chiba, Akira Okazaki, Hiroko Asanuma, Michio Mori, Shuji Takahashi, Minoru Okazaki, Kokichi Kikuchi, Eimei Narimatsu, Noriyuki Sato, Koichi Hirata |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Cancer Research
Receptor ErbB-2 medicine.drug_class Mammary gland Estrogen receptor Breast Neoplasms Breast cancer Hsp27 Heat shock protein medicine Humans HSP70 Heat-Shock Proteins Neoplasm Invasiveness Epidermal growth factor receptor skin and connective tissue diseases Heat-Shock Proteins Oncogene Proteins biology Tumor Suppressor Proteins Proteins Cancer Estrogens General Medicine medicine.disease Immunohistochemistry Neoplasm Proteins ErbB Receptors medicine.anatomical_structure Receptors Estrogen Oncology Estrogen Cancer research biology.protein Female Trefoil Factor-1 Tumor Suppressor Protein p53 |
| Zdroj: | Oncology. 52:371-375 |
| ISSN: | 1423-0232 0030-2414 |
| DOI: | 10.1159/000227491 |
| Popis: | The authors immunohistochemically studied the expression of the estrogen receptor (ER), 27-kD heat shock protein (HSP27) and pS2 in 118 invasive primary human breast cancers. Positive nuclear staining of the ER was detected in 64% of the cases and was closely correlated with the biochemical assay (p0.0001). ER-positive tumors were significantly decreased with tumor size and stage (p0.001 each), but not with lymph node status. Positivity of the ER was correlated with the cytoplasmic expression of HSP27 (p0.005), pS2 (not significant) and HSP70 (not significant). ER negativity was significantly correlated with the expression of p53, epidermal growth factor receptor (EGFR) and c-erbB-2 (p0.05 each). Thus, it was concluded that ER-positive breast carcinomas, relatively small in size, preferentially expressed HSP27, HSP70 and pS2 and that ER-negative tumors, relatively large in size, were predisposed to express p53, EGFR and c-erbB-2. |
| Databáze: | OpenAIRE |
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