Modulation of frontal gamma oscillations improves working memory in schizophrenia
| Autor: | I-Wei Shu, Jaime A. Pineda, Eric Granholm, Sheng-Hsiou Hsu, Peter C. Link, Fiza Singh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
WM
working memory Audiology Neuropsychological Tests lcsh:RC346-429 0302 clinical medicine N-back 2.1 Biological and endogenous factors GBR gamma band response Aetiology n-back Gamma power 05 social sciences Neuropsychology Cognition Neurofeedback Serious Mental Illness Frontal Lobe SCZ Schizophrenia Memory Short-Term Mental Health Neurology Cognitive remediation therapy Schizophrenia Neurological lcsh:R858-859.7 Cognitive remediation medicine.medical_specialty Cognitive Neuroscience Clinical Trials and Supportive Activities lcsh:Computer applications to medicine. Medical informatics 050105 experimental psychology EEG electroencephalogram 03 medical and health sciences Memory Clinical Research Behavioral and Social Science medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Gamma lcsh:Neurology. Diseases of the nervous system NFB Neurofeedback Working memory business.industry Neurosciences medicine.disease Brain Disorders Good Health and Well Being Short-Term Neurology (clinical) business Cognition Disorders Mind and Body 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage: Clinical, Vol 27, Iss, Pp 102339-(2020) NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| Popis: | Highlights • Cognitive deficits, a core symptom of schizophrenia, are difficult to treat with available therapies. • Abnormal neural dynamics of frontal gamma oscillations contribute to these deficits. • Neurofeedback has been used previously to alter brain oscillations. • Gamma band neurofeedback can impact brain and behavioral markers of cognition. Schizophrenia is a debilitating mental disorder that is associated with cognitive deficits. Impairments in cognition occur early in the course of illness and are associated with poor functional outcome, but have been difficult to treat with conventional treatments. Recent studies have implicated abnormal neural network dynamics and impaired connectivity in frontal brain regions as possible causes of cognitive deficits. For example, high-frequency, dorsal-lateral prefrontal oscillatory activity in the gamma range (30–50 Hz) is associated with impaired working memory in individuals with schizophrenia. In light of these findings, it may be possible to use EEG neurofeedback (EEG-NFB) to train individuals with schizophrenia to enhance frontal gamma activity to improve working memory and cognition. In a single-group, proof-of-concept study, 31 individuals with schizophrenia received 12 weeks of twice weekly EEG-NFB to enhance frontal gamma band response. EEG-NFB was well-tolerated, associated with increased gamma training threshold, and significant increases in frontal gamma power during an n-back working memory task. Additionally, EEG-NFB was associated with significant improvements in n-back performance and working memory, speed of processing, and reasoning and problem solving on neuropsychological tests. Change in gamma power was associated with change in cognition. Significant improvements in psychiatric symptoms were also found. These encouraging findings suggest EEG-NFB targeting frontal gamma activity may provide a novel effective approach to cognitive remediation in schizophrenia, although placebo-controlled trials are needed to assess the effects of non-treatment related factors. |
| Databáze: | OpenAIRE |
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