Scutellaria barbata: A Review on Chemical Constituents, Pharmacological Activities and Clinical Applications
Autor: | Su-Juan Wang, Khalid Rahman, Qiong Chen, Hong Zhang, Shuang Zhou |
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Rok vydání: | 2020 |
Předmět: |
Pharmacology
RM 0303 health sciences Traditional medicine biology Plant Extracts Scutellaria business.industry Phytochemicals Traditional Chinese medicine Blood stasis biology.organism_classification Toxic material 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Blood circulation Chemical constituents Drug Discovery Medicine Medicine Chinese Traditional business Scutellaria barbata Phytotherapy 030304 developmental biology |
Zdroj: | Current Pharmaceutical Design. 26:160-175 |
ISSN: | 1381-6128 |
Popis: | Scutellaria barbata has a long history of medical use in Traditional Chinese Medicine for removing heat and toxic material, promoting blood circulation and removing blood stasis, and inducing diuresis to reduce edema. Recent pharmacology investigations have provided evidence for its anti-cancer, bacteriostasis, anti-virus, anti-inflammation, anti-oxidation and immunity enhancement properties. The efficacy of activating blood circulation and removing blood stasis has unique advantages in the treatment of cardiovascular and cerebrovascular diseases. A total of 84 compounds have been isolated from S. barbata and are characterized mainly as flavonoids, diterpenoids, followed by polysaccharide, volatile oil and steroids. Peer-reviewed articles published over the last few years were gathered by consulting the databases PubMed, Elsevier, Springer, and Chinese Herbal Classics. This review mainly focuses on the pharmacologically active constituents isolated from S. barbata,which have been subjected to in vitro and/or in vivo studies. Although, the chemical components, pharmacological activities, toxicology, clinical applications and mechanisms of action of S. barbata have been investigated, many constituents remain unknown. Further investigations are required to investigate the medicinal properties of S. barbata. |
Databáze: | OpenAIRE |
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