Relation between responses to induction chemotherapy and subsequent radiotherapy in advanced or multicentric squamous cell carcinomas of the head and neck
| Autor: | Tan-Dat Nguyen, Michel Legros, Paul Coninx, X. Panis |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Continuous infusion medicine.medical_treatment Cell Drug Administration Schedule Antineoplastic Combined Chemotherapy Protocols Humans Medicine Radiology Nuclear Medicine and imaging Stage (cooking) Head and neck Etoposide Aged Chemotherapy Radiation business.industry Induction chemotherapy Middle Aged Combined Modality Therapy Surgery Radiation therapy medicine.anatomical_structure Oncology Head and Neck Neoplasms Carcinoma Squamous Cell Fluorouracil Cisplatin business Nuclear medicine medicine.drug |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 18:1315-1318 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/0360-3016(90)90303-2 |
| Popis: | Between 1984 and 1986, 85 consecutive patients with Stage III-IV or multi-centric squamous cell carcinoma of the head and neck were given three courses of chemotherapy followed by curative external radiotherapy. Induction chemotherapy consisted of either DDP (100 mg/m2, d 1) + 5 FU (1 g/m2/d, d 1-5, continuous infusion) or DDP (100 mg/m2, d4) + Etoposide (60 mg/m2/d, d 1-5, intravenously). Radiotherapy was delivered 70 Gy over 7 weeks in gross tumor and palpable nodes and 50 Gy over 5 weeks in clinically negative nodal areas. Complete response (CR) rates of both the chemotherapies were 39% for the primary and 20% for the nodes whereas partial response (PR) rates were 22% and 40%, respectively. Six months after completion of radiotherapy, 70% of the primaries and 63% of the nodes achieved complete response. The analysis of responses to chemotherapy on one hand and to subsequent radiotherapy on the other shows that the response to chemotherapy can be regarded as predictive for subsequent radiotherapy (p less than 0.001) except in T1-T2 tumors. In these early stages radiotherapy can be efficacious despite a previous failure of chemotherapy (p less than 0.01). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|