CTLA-4 and multiple sclerosis: the A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population
| Autor: | Bradley N. Wray, Brendan J. McMorran, Ingrid van der Mei, Jim Stankovich, Joanne L. Dickinson, Bruce V. Taylor, Lucy Whittock, Anne-Louise Ponsonby, Terence Dwyer, Simon J. Foote |
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| Rok vydání: | 2007 |
| Předmět: |
Multiple Sclerosis
Genotype Immunology Neurogenetics Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Gene Frequency Antigens CD medicine Immunology and Allergy SNP Humans CTLA-4 Antigen Genetic Predisposition to Disease Allele frequency Genetic association Genetics Multiple sclerosis Haplotype Australia HLA-DR Antigens medicine.disease Neurology Neurology (clinical) |
| Zdroj: | Journal of neuroimmunology. 196(1-2) |
| ISSN: | 0165-5728 |
| Popis: | Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single nucleotide polymorphism (SNP) genotype of the CTLA-4 gene influenced the development of MS in Southern Australians as well as the interaction of this SNP with the DRB1*15 haplotype. There were no significant (P |
| Databáze: | OpenAIRE |
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