Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis

Autor: Vincent Sapin, Nathalie Pinol-Domenech, Julie A. Bastarache, Hanifa Boukail, Jules Audard, Michael A. Matthay, Matthieu Jabaudon, Carolyn S. Calfee, Nicole P. Juffermans, Dominique Morand, Bruno Pereira, Lorraine B. Ware, Ruoyang Zhai, Céline Lambert, Manuela De Carvalho, Patricia R. M. Rocco, John G. Laffey, Adrien Carla, Antonio Artigas, Jean-Michel Constantin, Raiko Blondonnet, Lieuwe D. J. Bos, Daniel F. McAuley
Přispěvatelé: CHU Clermont-Ferrand, Unité de Biostatistiques [CHU Clermont-Ferrand], Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Génétique, Reproduction et Développement (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Bibliothèque Université Clermont Auvergne (BUCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Vanderbilt University Medical Center [Nashville], Vanderbilt University [Nashville], University of California [San Francisco] (UC San Francisco), University of California (UC), The Hospital for sick children [Toronto] (SickKids), University of Toronto, VU University Medical Center [Amsterdam], University of Barcelona, Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), University of California [San Francisco] (UCSF), University of California
Jazyk: angličtina
Rok vydání: 2020
Předmět:
ARDS
[SDV]Life Sciences [q-bio]
Clinical Sciences
Respiratory System
MEDLINE
Acute respiratory distress
Lung injury
Cardiorespiratory Medicine and Haematology
Bioinformatics
[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
Positive-Pressure Respiration
03 medical and health sciences
Study Protocol
0302 clinical medicine
Rare Diseases
Medicine
Animals
Humans
030212 general & internal medicine
Lung
Randomized Controlled Trials as Topic
Protocol (science)
lcsh:RC705-779
Respiratory Distress Syndrome
ESICM Translational Biology Group of the Acute Respiratory Failure section
Acute respiratory distress syndrome
business.industry
Animal
Consensus conference
lcsh:Diseases of the respiratory system
Adrenergic beta-Agonists
medicine.disease
Subphenotypes
Preclinical
3. Good health
Systematic review protocol
Disease Models
Animal
medicine.anatomical_structure
Phenotype
Treatment Outcome
030228 respiratory system
Meta-analysis
Disease Models
Respiratory
business
Zdroj: Respiratory Research
Respiratory research, vol 21, iss 1
Respiratory Research, Vol 21, Iss 1, Pp 1-10 (2020)
Respiratory Research, 2020, 21 (1), pp.81. ⟨10.1186/s12931-020-01337-9⟩
Respiratory Research, BioMed Central, 2020, 21 (1), pp.81. ⟨10.1186/s12931-020-01337-9⟩
ISSN: 1465-993X
1465-9921
DOI: 10.1186/s12931-020-01337-9⟩
Popis: Background Subphenotypes were recently reported within clinical acute respiratory distress syndrome (ARDS), with distinct outcomes and therapeutic responses. Experimental models have long been used to mimic features of ARDS pathophysiology, but the presence of distinct subphenotypes among preclinical ARDS remains unknown. This review will investigate whether: 1) subphenotypes can be identified among preclinical ARDS models; 2) such subphenotypes can identify some responsive traits. Methods We will include comparative preclinical (in vivo and ex vivo) ARDS studies published between 2009 and 2019 in which pre-specified therapies were assessed (interleukin (IL)-10, IL-2, stem cells, beta-agonists, corticosteroids, fibroblast growth factors, modulators of the receptor for advanced glycation end-products pathway, anticoagulants, and halogenated agents) and outcomes compared to a control condition. The primary outcome will be a composite of the four key features of preclinical ARDS as per the American Thoracic Society consensus conference (histologic evidence of lung injury, altered alveolar-capillary barrier, lung inflammatory response, and physiological dysfunction). Secondary outcomes will include the single components of the primary composite outcome, net alveolar fluid clearance, and death. MEDLINE, Embase, and Cochrane databases will be searched electronically and data from eligible studies will be extracted, pooled, and analyzed using random-effects models. Individual study reporting will be assessed according to the Animal Research: Reporting of In Vivo Experiments guidelines. Meta-regressions will be performed to identify subphenotypes prior to comparing outcomes across subphenotypes and treatment effects. Discussion This study will inform on the presence and underlying pathophysiological features of subphenotypes among preclinical models of ARDS and should help to determine whether sufficient evidence exists to perform preclinical trials of subphenotype-targeted therapies, prior to potential clinical translation. Systematic review registration PROSPERO (ID: CRD42019157236).
Databáze: OpenAIRE
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