Systematic Review of Research Methods and Reporting Quality of Randomized Clinical Trials of Spinal Cord Stimulation for Pain
| Autor: | John D. Markman, Ewan McNicol, Kathleen M. Bungay, Dennis C. Turk, Sam Eldabe, McKenzie C Ferguson, Nathaniel P. Katz, Richard B. North, Robert H. Dworkin, Jennifer S. Gewandter, Brian H. Kopell, Emily Rowe, Rod S Taylor, Salim M. Hayek, Simon Thomson, Ali R. Rezai |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty media_common.quotation_subject MEDLINE law.invention Angina 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Quality of life 030202 anesthesiology law Outcome Assessment Health Care Humans Pain Management Medicine Quality (business) Adverse effect Aged Randomized Controlled Trials as Topic media_common Protocol (science) Spinal Cord Stimulation business.industry Middle Aged medicine.disease Data Accuracy Anesthesiology and Pain Medicine Systematic review Neurology Research Design Physical therapy Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Pain. 22:127-142 |
| ISSN: | 1526-5900 |
| DOI: | 10.1016/j.jpain.2020.05.001 |
| Popis: | This systematic review assessed design characteristics and reporting quality of published randomized clinical trials of spinal cord stimulation (SCS) for treatment of pain in adults and adolescents. The study protocol was registered with PROSPERO (CRD42018090412). Relevant articles were identified by searching the following databases through December 31, 2018: MEDLINE, Embase, WikiStim, The Cochrane Database of Systematic Reviews, and The Cochrane Central Register of Controlled Trials. Forty-six studies were included. Eighty-seven percent of articles identified a pain-related primary outcome. Secondary outcomes included physical functioning, health-related quality of life, and reductions in opioid use. Nineteen of the 46 studies prespecified adverse events as an outcome, with 4 assessing them as a primary outcome. Eleven studies stated that they blinded participants. Of these, only 5 were assessed as being adequately blinded. The number of participants enrolled was generally low (median 38) and study durations were short (median 12 weeks), particularly in studies of angina. Fifteen studies employed an intention-to-treat analysis, of which only seven specified a method to accommodate missing data. Review of these studies identified deficiencies in both reporting and methodology. The review's findings suggest areas for improving the design of future studies and increasing transparency of reporting. Perspective This article presents a systematic review of research methods and reporting quality of randomized clinical trials of SCS for the treatment of various pain complaints. The review identifies deficiencies in both methodology and reporting, which may inform the design of future studies and improve reporting standards. |
| Databáze: | OpenAIRE |
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