Acanthosis nigricans predicts the clustering of metabolic syndrome components in Hispanic elementary school-aged children
| Autor: | Emilie Sebesta, Betty J. Skipper, John Leggott, Mark R. Burge, Alberta S. Kong, Laura Vanderbloemen, Robert Glew |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty New Mexico Endocrinology Diabetes and Metabolism Comorbidity Article Body Mass Index Endocrinology Insulin resistance Internal medicine Prevalence medicine Hyperinsulinemia Humans Acanthosis Nigricans Child Acanthosis nigricans Family Health Metabolic Syndrome business.industry Hispanic or Latino medicine.disease Obesity Cross-Sectional Studies Child Preschool Pediatrics Perinatology and Child Health Female Insulin Resistance Metabolic syndrome Abnormality business Body mass index |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. 25 |
| ISSN: | 2191-0251 0334-018X |
| DOI: | 10.1515/jpem-2012-0117 |
| Popis: | Acanthosis nigricans (AN) is a dermatologic condition associated with hyperinsulinemia, a marker of insulin resistance that is the principal abnormality in metabolic syndrome (MetS). We examined the association of AN with the clustering of MetS components.A cross-sectional study was conducted in an urban school-based health center in New Mexico. Students without diabetes were evaluated for AN, a family history of type 2 diabetes, body mass index (BMI), and MetS components. The clustering of MetS components by BMI category and AN status was assessed by comparing the group means of summed average z-scores of fasting insulin, triglycerides, high-density lipoprotein-cholesterol, and systolic blood pressure among the students. A multivariate model with BMI category and AN status controlling for Tanner stage was performed to identify the variables associated with the clustering of MetS components.Complete data were available for 90 children (age, 9.7±1.4 years; 94% Hispanic; 60% female). In multivariate modeling of MetS cluster z-score, significant differences were found between the students with BMI85th percentile [-0.27; 95% confidence interval (95% CI)=-0.42 to -0.11] and (a) the students with BMI 85th-94.9th percentile with AN (0.74; 95% CI=0.17-1.31) and (b) the students with BMI ≥95th percentile with AN (0.86; 95% CI=0.54-1.18). No significant differences in the MetS cluster z-score were seen between the students with BMI85th percentile and those with BMI 85th-94.9th percentile without AN (0.24; 95% CI=-0.33 to 0.81) or those with BMI ≥95th percentile without AN (0.31; 95% CI=-0.13 to 0.75).Overweight/obese Hispanic elementary school-aged children with AN exhibit clustering of MetS components and could benefit from early intervention. |
| Databáze: | OpenAIRE |
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