Synthesis, antifungal and antimicrobial activity of alkylphospholipids
| Autor: | Katrina A. Jolliffe, Lesley C. Wright, Tania C. Sorrell, Daniel Obando, Fred Widmer |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Antifungal Agents
Erythrocytes medicine.drug_class Stereochemistry Clinical Biochemistry Pharmaceutical Science Carboxamide Alkylphosphocholine Biochemistry Chemical synthesis Structure-Activity Relationship chemistry.chemical_compound Drug Discovery medicine Molecular Biology Phospholipids Antibacterial agent Miltefosine Bacteria Molecular Structure Organic Chemistry Fungi Antimicrobial Combinatorial chemistry Anti-Bacterial Agents chemistry Molecular Medicine Antibacterial activity Edelfosine medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry. 15:5158-5165 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/j.bmc.2007.05.028 |
| Popis: | The antifungal, antibacterial and haemolytic activity of a series of alkylphosphocholines (e.g., miltefosine) and alkylglycerophosphocholines (e.g., edelfosine) has been investigated. These compound classes exhibit significant antifungal and moderate antibacterial activities. Several new alkylphosphocholine derivatives with amide or ester bonds in the alkyl chain have been synthesised. These compounds show much lower haemolytic activity than miltefosine. Alkylphosphocholines and alkylglycerophosphocholines show significant promise as novel orally available antifungal and antibacterial therapeutics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect