Intermittent fasting decreases oxidative stress parameters in Wistar rats (Rattus norvegicus)
| Autor: | Abdulhalim Ahmad Najmuddin, Endah Kusumawardani, Shindy Yudha Utami, Titis Nurmasitoh, Ika Fidianingsih |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
MDA Blood lipids Intermittent fasting medicine.disease_cause chemistry.chemical_compound High-density lipoprotein Internal medicine medicine oxidative stress medicine.diagnostic_test Cholesterol business.industry Malondialdehyde rats lipid profile Endocrinology chemistry Medicine Lipid profile business Oxidative stress diet restriction Lipoprotein |
| Zdroj: | Universa Medicina, Vol 37, Iss 1 (2018) |
| ISSN: | 2407-2230 1907-3062 |
| Popis: | BackgroundChronic and degenerative diseases are closely related to modern lifestyles that tend to be deficient in physical activity but excessive in food intake. One method used to overcome this problem is dietary restriction through intermittent fasting. Intermittent fasting decreases the risk of chronic and degenerative diseases, e.g. by lowering oxidative stress. Oxidative stress can be determined from the malondialdehyde (MDA) levels and lipid profile in the blood. The present study aimed to determine the effect of intermittent fasting on plasma MDA levels and lipid profile of Wistar rats (Rattus norvegicus).MethodsThis research was a laboratory experimental research using a post test control group design. Twenty four male Wistar rats (Rattus norvegicus) were randomly assigned to 4 groups, ie control group (C), fasting group (F), non-fasting obese group (NFO), and fasting obese group (FO). Fasting treatment given in this research was intermittent fasting, comprising one day of fasting for 12 hours alternating with one day of normal feed ad libitum in the span of 8 weeks. After completion of treatment, blood was taken transcardially for examination of MDA levels and lipid profiles using spectrophotometry.ResultsThere were significant between-group differences in MDA levels and lipid profiles (p |
| Databáze: | OpenAIRE |
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