Microwave-Assisted Synthesis of Phenothiazine and Qinoline Derivatives
| Autor: | Emanoil Surducan, Claudia Moldovan, Ioan A. Silberg, Abdalah Mahamoud, Luiza Gaina, Castelia Cristea, J. Barbe, Dan Porumb, Calin Deleanu |
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| Rok vydání: | 2007 |
| Předmět: |
Quinoline
Phenothiazine Chemical reaction Chemical synthesis Catalysis Pyrido[3 2-g]quinoline lcsh:Chemistry Inorganic Chemistry chemistry.chemical_compound Nucleophilic substitution Organic chemistry Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy formylation Organic Chemistry General Medicine Condensation reaction Computer Science Applications Formylation MAOS lcsh:Biology (General) lcsh:QD1-999 chemistry Organic synthesis |
| Zdroj: | International Journal of Molecular Sciences, Vol 8, Iss 2, Pp 70-80 (2007) International Journal of Molecular Sciences; Volume 8; Issue 2; Pages: 70-80 |
| ISSN: | 1422-0067 |
| Popis: | 1 “Babe s-Bolyai” University, Faculty of Chemistry and Chemical Engineering, Organic Chemistry Department, Cluj-Napoca-Ro E-mail: gluiza@chem.ubbcluj.ro, E-mail: castelia@chem.ubbcluj.ro , E-mail: pdan@chem.ubbcluj.ro 2 INCDTIM-Cluj-Napoca-Ro E-mail: esurducan@gmail.com 3 Institute of Organic Chemistry, National NMR Laboratory, Bucharest-Ro. E-mail: calind@rdslink.ro 4 Universitee de la Mediteranee, Faculte de Pharmacie, Marseille CEDEX 5, E-mail: barbe@pharmacie.univ-mrs.fr E-mail: mahamoud@pharmacie.univ-mrs.fr * Author to whom correspondence should be addressed. Received: 27 October 2006 / Accepted: 12 February 2007 / Published: 13 February 2007 Abstract: Application of a dynamic microwave power system in the chemical synthesis of some phenothiazine and quinoline derivatives is described. Heterocyclic ring formation, aromatic nucleophilic substitution and heterocyclic aldehydes/ketones condensation reactions were performed on solid support, or under solvent free reaction conditions. The microwave-assisted Duff formylation of phenothiazine was achieved. Comparison of microwave-assisted synthesis with the conventional synthetic methods demonstrates advantages related to shorter reaction times and in some cases better reaction yields. Keywords: MAOS, Quinoline, Pyrido[3,2-g]quinoline, Phenothiazine, formylation. 1. Introduction Microwave assisted organic synthesis became an increasingly popular technique in academic and industrial research laboratories, due to certain advantages, particularly shorter reaction times and rapid optimization of chemical reactions. The experimental technique applied for the organic syntheses described below, is based on microwave power processing of materials using a dynamic control of the microwave power magnetron |
| Databáze: | OpenAIRE |
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