Local and targeted drug delivery for bone regeneration
| Autor: | Danielle S. W. Benoit, Maureen R. Newman |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Drug Biodistribution Bone Regeneration media_common.quotation_subject Biomedical Engineering Bioengineering 02 engineering and technology Bioinformatics Article Bone and Bones 03 medical and health sciences Drug Delivery Systems Tissue engineering Animals Humans Medicine Bone regeneration media_common Tissue Engineering business.industry 021001 nanoscience & nanotechnology 030104 developmental biology Targeted drug delivery Drug delivery Intercellular Signaling Peptides and Proteins Healing bone 0210 nano-technology business Biotechnology |
| Zdroj: | Current Opinion in Biotechnology. 40:125-132 |
| ISSN: | 0958-1669 |
| Popis: | While experimental bone regeneration approaches commonly employ cells, technological hurdles prevent translation of these therapies. Alternatively, emulating the spatiotemporal cascade of endogenous factors through controlled drug delivery may provide superior bone regenerative approaches. Surgically placed drug depots have clinical indications. Additionally, noninvasive systemic delivery can be used as needed for poorly healing bone injuries. However, a major hurdle for systemic delivery is poor bone biodistribution of drugs. Thus, peptides, aptamers, and phosphate-rich compounds with specificity toward proteins, cells, and molecules within the regenerative bone microenvironment may enable the design of targeted carriers with bone biodistribution greater than that achieved by drug alone. These carriers, combined with osteoregenerative drugs and/or stimuli-sensitive linkers, may enhance bone regeneration while minimizing off-target tissue effects. |
| Databáze: | OpenAIRE |
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