Ionic co-crystals of racetams: solid-state properties enhancement of neutral active pharmaceutical ingredients via addition of Mg2+ and Ca2+ chlorides
| Autor: | Fabrizia Grepioni, Luc Quere, Gérard Coquerel, Geraldine Longfils, Sandrine Rome, Luc Aerts, Johan Wouters, Dario Braga, Saverio Nanna, Baptiste Fours |
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| Přispěvatelé: | Grepioni, Fabrizia, Wouters, Johan, Braga, Dario, Nanna, Saverio, Fours, Baptiste, Coquerel, Gérard, Longfils, Geraldine, Rome, Sandrine, Aerts, Luc, Quéré, Luc, Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), UCB Pharma S.A.[Braine-l'Alleud] |
| Rok vydání: | 2014 |
| Předmět: |
Diffraction
Active ingredient [CHIM.ORGA]Chemical Sciences/Organic chemistry Chemistry Inorganic chemistry Ionic bonding [CHIM.MATE]Chemical Sciences/Material chemistry [CHIM.THER]Chemical Sciences/Medicinal Chemistry General Chemistry Condensed Matter Physics Crystal engineering Crystal engineering pharmaceutical co-crystals crystallography Seletracetam Yield (chemistry) [CHIM.CRIS]Chemical Sciences/Cristallography Melting point medicine [CHIM]Chemical Sciences General Materials Science Single crystal ComputingMilieux_MISCELLANEOUS medicine.drug |
| Zdroj: | CrystEngComm CrystEngComm, Royal Society of Chemistry, 2014, 16 (26), pp.5887-5896. ⟨10.1039/C4CE00409D⟩ |
| ISSN: | 1466-8033 |
| Popis: | Mechanochemical and solution based reactions of solid brivaracetam (BRV) and seletracetam (SEL), antiepileptic drugs from UCB's pipeline, with the inorganic salts MgCl2 and CaCl2, yield ionic co-crystals with changed or improved physico-chemical properties with respect to pure drugs (melting point, hygroscopicity, crystal morphology). All co-crystals are characterized via a combination of solid-state techniques, i.e. single crystal and powder X-ray diffraction, variable temperature X-ray diffraction, DSC, TGA and hot-stage microscopy (HSM). |
| Databáze: | OpenAIRE |
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