Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging

Autor: Cinzia Dellanoce, Ettore Corradi, Alice Rizzardi, Renata De Maria, Maria Luisa Di Guglielmo, Patrizia Tarlarini, Marina Parolini, Maria Giovanna Trivella, Marina Cattaneo, Jonica Campolo
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Aging
Physiology
Biochemistry
Body Mass Index
Fats
0302 clinical medicine
Endocrinology
Medicine and Health Sciences
Insulin
Public and Occupational Health
Sex Characteristics
Multidisciplinary
Fatty liver
Middle Aged
Lipids
Body Fluids
Blood
Cholesterol
Physiological Parameters
Medicine
Female
Anatomy
Sex characteristics
Research Article
medicine.medical_specialty
Waist
Endocrine Disorders
Science
030209 endocrinology & metabolism
Blood Plasma
White People
03 medical and health sciences
Insulin resistance
Internal medicine
medicine
Diabetes Mellitus
Humans
Obesity
Exercise
Aged
Diabetic Endocrinology
business.industry
Body Weight
Biology and Life Sciences
Physical Activity
Anthropometry
medicine.disease
Impaired fasting glucose
Hormones
Fibronectins
030104 developmental biology
Metabolic Disorders
business
Body mass index
Biomarkers
Zdroj: PLoS ONE, Vol 15, Iss 2, p e0229152 (2020)
PLoS ONE
ISSN: 1932-6203
Popis: Irisin concentrations are decreased in subjects with overt diabetes and upregulated in those with obesity or impaired fasting glucose. However, gender-balanced data in older populations, in whom risk factors commonly culminate in overt cardiovascular disease, are scarce. We assessed in non-diabetic Caucasian subjects with stage I-II obesity in the early aging range (50 to 70 years), the relationship between irisin, body composition and markers of metabolic derangement by gender. In 60 (31 women, 29 men) non-diabetics with a body mass index ≥30 - ≤40 kg/m2, we measured anthropometrics and body composition (Air Displacement Plethysmography). We assayed lipid and glucose profile by routine methods, plasma irisin by ELISA and measured insulin resistance by the HOMA index. Irisin levels were higher in women than in men (161 [105-198]) vs 83 [33-115] ng/ml, P
Databáze: OpenAIRE
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