Hormone replacement therapy and hemostasis: Effects in Brazilian postmenopausal women
Autor: | Maria Regina Torqueti Toloi, Marlise Bonetti Agostinho Montes, Daniel R. Callejon, Silvio Antonio Franceschini |
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Rok vydání: | 2005 |
Předmět: |
Adult
medicine.medical_specialty Hormone Replacement Therapy medicine.medical_treatment Administration Oral Medroxyprogesterone Acetate General Biochemistry Genetics and Molecular Biology Internal medicine Fibrinolysis Contraceptive Agents Female medicine Humans Medroxyprogesterone acetate Prospective Studies Prothrombin time Hemostasis Estradiol medicine.diagnostic_test business.industry Fibrinogen Obstetrics and Gynecology Middle Aged Blood Coagulation Factors Postmenopause Treatment Outcome Endocrinology Coagulation Prothrombin Time Drug Therapy Combination Female Partial Thromboplastin Time business Plasminogen activator Brazil Protein C Follow-Up Studies circulatory and respiratory physiology medicine.drug Partial thromboplastin time |
Zdroj: | Maturitas. 52:249-255 |
ISSN: | 0378-5122 |
DOI: | 10.1016/j.maturitas.2005.02.024 |
Popis: | Objective: To evaluate the impact that administration of transdermal estradiol gel combined with medroxyprogesterone acetate (MPA) has on hemostasis. Methods: In this open prospective longitudinal study, thirty postmenopausal women received transdermal estradiol gel (1 mg/day) continuously combined with oral MPA (5 mg/day) for 12 days/month. The following parameters were determined: prothrombin time (PT), activated partial thromboplastin time (aPTT), factors VII, X, and XII activity, fibrinogen levels, thrombin-antithrombin complex levels, protein C and S antigen, antithrombin activity, plasminogen activator inhibitor type 1 (PAI-1) antigen, tissue-type plasminogen activator (t-PA) antigen, plasminogen activity and fibrin degradation products (FbDP) antigen. They were evaluated before and after 6 months of treatment. Results: There was a significant decrease in factor VII activity ( P = 0.001), factor X activity (P = 0.016), protein C antigen (P = 0.022), antithrombin activity (P = 0.025), plasminogen activity (P = 0.023), t-PA antigen (P = 0.043) and FbDP antigen (P = 0.048) compared with baseline values. Conclusion: The results suggest that the treatment with transdermal estradiol gel combined with MPA avoids any major activation of coagulation and does not produce any overall effect on fibrinolysis. Therefore, this treatment might provide interesting effects on hemostasis in postmenopausal Brazilian women. © 2005 Elsevier Ireland Ltd. All rights reserved. |
Databáze: | OpenAIRE |
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