Clindamycin-induced colitis
| Autor: | John R. Ebright, Robert Browne, Robert Fekety, G. D. Rifkin, Joseph Silva |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
medicine.medical_specialty Bacterial Toxins Medicine (miscellaneous) Hamster Gastroenterology Feces Vancomycin Internal medicine Cricetinae Metronidazole medicine Animals Humans Colitis Cecum Enterocolitis Pseudomembranous Enterocolitis Clostridium Nutrition and Dietetics biology Mesocricetus business.industry Clindamycin Clostridium difficile medicine.disease biology.organism_classification Disease Models Animal Clostridium Infections medicine.symptom business medicine.drug |
| Zdroj: | The American journal of clinical nutrition. 32(1) |
| ISSN: | 0002-9165 |
| Popis: | The hamster model of enterocolitis after the administration of clindamycin was used to study various drugs used in treatment of the disease in humans. Current evidence strongly suggests toxigenic, clindamycin-resistant Clostridium difficile is a cause of the disease in hamster and man. This organism is susceptible to vancomycin and metronidazole, and the disease could be prevented in the hamster so long as the antibiotics were given orally. A fatal colitis almost invariably ensued once they were discontinued. Administration of cholestyramine significantly prolonged survival of hamsters, but did not pervent death or colitis. Corticosteroids or atropine-diphenoxylate (Lomotil) did not alter the disease. The hamster model may be useful in studying other kinds of treatment of this disease. |
| Databáze: | OpenAIRE |
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