Reactogenicity and immunogenicity of rotavirus WC3 vaccine in 5-12-month old infants
| Autor: | H.F. Clark, F. Bricout, L. Hessel, G. Le Moing, G. Lasfargues, A. Garbag-Chenon, J.-L. Fontaine, J. Guyot |
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| Rok vydání: | 1989 |
| Předmět: |
Rotavirus
Serotype Immunology Enzyme-Linked Immunosorbent Assay Antibodies Viral medicine.disease_cause Feces Species Specificity Virology medicine Humans Neutralizing antibody Reactogenicity biology business.industry Immunogenicity Infant Viral Vaccines Vaccination Immunization biology.protein Antibody business |
| Zdroj: | Research in Virology. 140:207-217 |
| ISSN: | 0923-2516 |
| Popis: | Rotavirus is a major cause of acute gastroenteritis in infants worldwide and there is need for an effective vaccine. Rotavirus Wistar calf 3 (WC3) is a strain of bovine origin attenuated by 12 passages in cell culture. A lyophilized candidate vaccine containing 1 x 10(7) PFU of WC3 has been developed. An oral dose was given to 25 French infants 5-12-months old (mean age 8.6 months). No diarrhoea was observed within 2 weeks after vaccination. Unexplained vomiting was reported once and isolated fever greater than 37.8 degrees C was reported 3 times during the first week. One month later, a neutralizing antibody response to serotypes tested was shown in 88% of cases, with heterotypic responses to human serotype 3 (SA11 strain) in 72% and to type 1 (WA strain) in 48%. The percentage of immune response was similar whether the infant had antibody prior to immunization or not, but a booster effect was observed in children who had pre-immunization rotavirus antibodies. Considering these promising results, efficacy trials are in the planning in different parts of the world. |
| Databáze: | OpenAIRE |
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