Design and characterization of chitosan/citrate films as carrier for oral macromolecule delivery
| Autor: | Géza Regdon, Mohamed E. Adam, András Kelemen, Elnazeer I. Hamedelniel, Katalin Kristó, Tamás Sovány, Yousif H-E. Y. Ibrahim |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Surface Properties Pharmaceutical Science Excipient Administration Oral 02 engineering and technology Polyethylene glycol 030226 pharmacology & pharmacy Chitosan 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Spectroscopy Fourier Transform Infrared Mucoadhesion medicine Citrates Solubility chemistry.chemical_classification Drug Carriers Plasticizer Polymer Permeation 021001 nanoscience & nanotechnology chemistry Chemical engineering 0210 nano-technology medicine.drug |
| Zdroj: | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 146 |
| ISSN: | 1879-0720 |
| Popis: | The oral delivery of biopharmaceuticals requires the including of absorption enhancer, protease inhibitor and a suitable carrier system. The aim of the present work was to formulate and characterize chitosan solutions/films incorporating citric acid (CA) as potential excipient in comparison to the well-known acetic acid (AA)-based films as a reference. Films were made by the solvent casting method with/without glycerol (G), propylene glycol (PG) and polyethylene glycol (PEG-400) as plasticizers. The minimum film forming temperature (MFFT) of the prepared solutions, film thickness, hardness/deformation, mucoadhesivity, moisture content, FT-IR spectra and surface free energy (SFE) were investigated. Chitosan has been reported as a safe and effective paracellular absorption enhancer for hydrophilic macromolecules, therefore there would be more rationale for incorporating CA as a solubility enhancer, a permeation enhancer and an enzyme inhibitor. CA shows good cross-linking, an ideal plasticizing property and increases both tensile strength and mucoadhesivity, thus its incorporation simplifies the formulation while improving effectiveness. We concluded that CA (3.5, 4 and 5 w/v %)-based chitosan solution could be used as a novel coating/subcoating polymer for oral macromolecule delivery, or as oral mucoadhesive films. |
| Databáze: | OpenAIRE |
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