Alternating sources of perisomatic inhibition during behavior
| Autor: | Jordane Dimidschstein, Attila Losonczy, Olivia Fong, John C. Bowler, Hongkui Zeng, Brian Lee, Gergely G. Szabo, Ivan Soltesz, Jordan S. Farrell, Ernie Hwaun, Jim Berg, Bosiljka Tasic, Peter M. Klein, Zizhen Yao, Barna Dudok, Fraser T. Sparks, Tanya L. Daigle, Satoshi Terada, Gord Fishell |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Interneuron Hippocampus Mice Transgenic Hippocampal formation Inhibitory postsynaptic potential Synaptic Transmission 03 medical and health sciences 0302 clinical medicine Basket cell Interneurons medicine Animals CA1 Region Hippocampal biology Chemistry General Neuroscience Pyramidal Cells digestive oral and skin physiology Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Parvalbumins nervous system biology.protein GABAergic Female Pyramidal cell Cholecystokinin Neuroscience hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Parvalbumin |
| Zdroj: | Neuron. 109(6) |
| ISSN: | 1097-4199 |
| Popis: | Summary Interneurons expressing cholecystokinin (CCK) and parvalbumin (PV) constitute two key GABAergic controllers of hippocampal pyramidal cell output. Although the temporally precise and millisecond-scale inhibitory regulation of neuronal ensembles delivered by PV interneurons is well established, the in vivo recruitment patterns of CCK-expressing basket cell (BC) populations has remained unknown. We show in the CA1 of the mouse hippocampus that the activity of CCK BCs inversely scales with both PV and pyramidal cell activity at the behaviorally relevant timescales of seconds. Intervention experiments indicated that the inverse coupling of CCK and PV GABAergic systems arises through a mechanism involving powerful inhibitory control of CCK BCs by PV cells. The tightly coupled complementarity of two key microcircuit regulatory modules demonstrates a novel form of brain-state-specific segregation of inhibition during spontaneous behavior. |
| Databáze: | OpenAIRE |
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