Hydrazine in the Ugi Tetrazole Reaction

Autor:	Ji Zhang, Alexander Dömling, Justyna Kalinowska-Tłuścik, Pravin Patil, Katarzyna Kurpiewska
Přispěvatelé:	Drug Design, Medicinal Chemistry and Bioanalysis (MCB)
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Hydrazine 01 natural sciences Chemical reaction High yielding proton nuclear magnetic resonance chemistry.chemical_compound Proton transport Organic chemistry tert butyl 2 [1 [1 benzyl 4 [1 (4 chlorobenzyl) 1h tetrazol 5 yl]piperidin 4 yl]]hydrazine 1 carboxylic acid Tetrazole tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl)(cyclohexyl)methyl]hydrazine 1 carboxylic acid tert butyl 2 [2 chloro 1 [1 (4 chlorobenzyl) 1h tetrazol 5 yl]ethyl]hydrazine 1 carboxylic acid tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl) 2 methylpropyl]hydrazine 1 carboxylic acid mass spectrometry tert butyl 2 [3 methyl 1 (1 phenethyl 1h tetrazol 5 yl)butyl]hydrazine 1 carboxylic acid tert butyl 2 [cyclohexyl(1 cyclohexyl 1h tetrazol 5 yl)methyl]hydrazine 1 carboxylic acid deprotection reaction supercritical fluid chromatography article hydrazine Ugi tetrazole reaction unclassified drug tert butyl 2 [2 [1 (4 chlorobenzyl) 1h tetrazol 5 yl]butan 2 yl]hydrazine 1 carboxylic acid chemical reaction tert butyl 2 [1 chloro 2 [1 (4 chlorobenzyl) 1h tetrazol 5 yl]propan 2 yl]hydrazine 1 carboxylic acid multicomponent reaction drug isolation Electrospray mass spectrometry One-pot synthesis tert butyl 2 [2 methyl 1 (1 phenethyl 1h tetrazol 5 yl)propyl]hydrazine 1 carboxylic acid tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl) 3 methylbutyl]hydrazine 1 carboxylic acid 010402 general chemistry electrospray mass spectrometry one pot synthesis Catalysis isocyanides tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl) 2 phenylethyl]hydrazine 1 carboxylic acid tert butyl 2 [1 (1 phenethyl 1h tetrazol 5 yl)cyclohexyl]hydrazine 1 carboxylic acid drug screening tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl) 3 phenylpropyl]hydrazine 1 carboxylic acid 010405 organic chemistry Organic Chemistry carbon nuclear magnetic resonance tert butyl 2 [cyclohexyl (1 phenethyl 1h tetrazol 5 yl)methyl]hydrazine 1 carboxylic acid 0104 chemical sciences benzyl 4 [2 (tert butoxycarbonyl)hydrazino] 4[1 [2 (1h indol 3 yl)ethyl] 1h tetrazol 5 yl]piperidine 1 carboxylic acid hydrazine derivative Ugi reaction chemistry tert butyl 2 [2 [1 (1 methoxy 4 methyl 1 oxopentan 2 yl) 1h tetrazol 5 yl]propan 2 yl]hydrazine 1 carboxylic acid tert butyl 2[1 (1 tert butyl 1h tetrazol 5 yl) 3 phenylpropyl]hydrazine 1 carboxylic acid proton transport tetrazoles
Zdroj:	Synthesis, 48(8), 1122-1130. GEORG THIEME VERLAG KG
ISSN:	1437-210X 0039-7881
Popis:	We describe the hitherto unknown use of N-Boc-protected hydrazine in the Ugi tetrazole reaction to access a library of highly substituted 5-(hydrazinomethyl)-1-methyl-1H-tetrazoles. The reaction is very versatile and good to high yielding. A one-pot, two-step procedure is given.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cdd67e04d29021cee37957a4d07333 https://research.rug.nl/en/publications/539d7505-f8f8-4c3c-a96d-9570d4589751 Zobrazit plný text záznamu