Fibroblast growth factor-21 concentration in serum and synovial fluid is associated with radiographic bone loss of knee osteoarthritis
| Autor: | Kong-Zu Hu, Zu-De Liu, Mao-Qiang Li, Wei-li Wang, Ji-Dong Zhang, Zhanchun Li, Gang Wang, Tao Ma, Jie Xiao |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty FGF21 Radiography Clinical Biochemistry Adipokine Enzyme-Linked Immunosorbent Assay Osteoarthritis Gastroenterology Internal medicine Synovial Fluid medicine Synovial fluid Humans Aged business.industry General Medicine Middle Aged Osteoarthritis Knee medicine.disease Surgery Fibroblast Growth Factors Potential biomarkers Case-Control Studies Biomarker (medicine) Osteoporosis Female business Grading scale Biomarkers |
| Zdroj: | Scandinavian journal of clinical and laboratory investigation. 75(2) |
| ISSN: | 1502-7686 |
| Popis: | We aimed to evaluate whether FGF-21 concentration in serum and synovial fluid (SF) is associated with radiographic bone loss of knee osteoarthritis (OA). A total of 186 OA patients and 108 controls were recruited. The radiographic bone loss of knee OA was assessed by the Ahlback grading scale. FGF-21 concentration in serum and SF was measured by enzyme-linked immunosorbent assay (ELISA). We demonstrated that OA patients had significantly higher serum FGF-21 concentration compared with controls (204.30 [range 158.25-279.16] ng/L vs. 130.72 [range 94.93-218.03] ng/L, p < 0.01). FGF-21 concentration in serum was well correlated with that in paired SF samples (r = 0.668, p < 0.001). In OA patients, those with a higher Ahlback grade had significantly higher serum and SF FGF-21 concentration (p < 0.001 for both). FGF-21 concentration in serum and SF was significantly and independently associated with the Ahlback grade (r = 0.403, p < 0.001 and r = 0.410, p < 0.001; respectively). These findings indicated that FGF-21 might be a potential biomarker for predicting bone loss of OA. Therapeutic interventions by blocking FGF-21 signaling pathways to delay the degenerative process of OA warrants further investigations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |