Cascarinoids A–C, a Class of Diterpenoid Alkaloids with Unpredicted Conformations from Croton cascarilloides

Autor:	Yao-Yue Fan, Yan-Sheng Xu, Xin-Hua Gao, Jianping Zuo, Li-She Gan, Jian-Min Yue
Rok vydání:	2017
Předmět:	Croton cascarilloides Molecular Structure 010405 organic chemistry Chemistry Stereochemistry Organic Chemistry Molecular Conformation 010402 general chemistry 01 natural sciences Biochemistry Terpenoid 0104 chemical sciences Alkaloids Croton Diterpenes Physical and Theoretical Chemistry
Zdroj:	Organic Letters. 20:228-231
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.7b03592
Popis:	Cascarinoids A-C (1-3), a new class of diterpenoid alkaloids with unpredicted conformations, were isolated and structurally characterized from Croton cascarilloides. It was demonstrated that the dispersion interaction might be one of the main contributors that stabilized the folded conformations for compounds 1-3. Compounds 2 and 3 showed moderate immunosuppressive activity against T and/or B lymphocyte cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cb4dc8c6f0b27332e986f215d9c9a8 https://doi.org/10.1021/acs.orglett.7b03592 Zobrazit plný text záznamu