The effects of remodeling with heart failure on mode of initiation of ventricular fibrillation and its spatiotemporal organization
| Autor: | Thomas H. Everett, Jeffrey E. Olgin, George S. Hulley, Roger Chang, Emily E. Wilson, Ken W. Lee |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Cardiorespiratory Medicine and Haematology Cardiovascular Article Dogs Spatio-Temporal Analysis Heart Conduction System Models Physiology (medical) Internal medicine Medicine Animals Ventricular remodeling Papillary muscle Heart Failure Ventricular Remodeling business.industry Extramural Body Surface Potential Mapping Models Cardiovascular Dominant frequency medicine.disease Fourier analysis Cross section (geometry) medicine.anatomical_structure Heart Disease Mapping Cardiovascular System & Hematology Heart failure Ventricular fibrillation Ventricular Fibrillation cardiovascular system Cardiology Action potential duration Cardiology and Cardiovascular Medicine business Alternans |
| Zdroj: | Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, vol 43, iss 3 |
| Popis: | PurposeThe effect of the heart failure substrate on the initiation of ventricular fibrillation (VF) and its resulting mechanism is not known. The objective of this study was to determine the effects of substrate on VF initiation and its spatiotemporal organization in the heart failure model.MethodsOptical action potentials were recorded from LV wedge preparations either from structurally normal hearts (control, n = 11) or from congestive heart failure (CHF; n = 7), at the epicardial surface, endocardial surface which included a papillary muscle, and a transmural cross section. Action potential duration (APD(80)) was determined, and VF was initiated. A fast Fourier transform was calculated, and the dominant frequency (DF) was determined.ResultsThe CHF group showed increased VF vulnerability (69 vs 26 %, p |
| Databáze: | OpenAIRE |
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