Fatty acid composition of erythrocyte membrane lipid obtained from children suffering from kwashiorkor and marasmus
| Autor: | K. Narayanareddy, Ayyalasomayajula Vajreswari, P.Srinivasa Rao |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Chromatography Gas Endocrinology Diabetes and Metabolism Linoleic acid Membrane lipids Palmitic Acid Oleic Acids Palmitic Acids Biology Protein-Energy Malnutrition Palmitic acid chemistry.chemical_compound Membrane Lipids Endocrinology Reference Values Internal medicine medicine Humans Erythrocyte Membrane Fatty Acids Kwashiorkor Infant Lipid metabolism medicine.disease Oleic acid chemistry Child Preschool Fatty Acids Unsaturated Marasmus Arachidonic acid Oleic Acid |
| Zdroj: | Metabolism: clinical and experimental. 39(8) |
| ISSN: | 0026-0495 |
| Popis: | The fatty acid composition of erythrocyte membrane (EM) lipids obtained from normal, kwashiorkor, and marasmic children was analyzed by gas chromatography. The proportion of palmitic acid (16:0) was lower and of oleic acid (18:1) higher in the kwashiorkor group than in the control group. The marasmic group showed lower proportions of eicosatrienoic acid (20:3) and arachidonic acid (20:4) and a higher proportion of oleic acid (18:1) than the control group. A significant difference was found between the marasmic and kwashiorkor groups with respect to arachidonic acid (20:4), which showed a lower proportion in the former group than the latter. The ratio of arachidonic acid to linoleic acid (20:4/18:2) was markedly lower in the marasmic group than the control group, suggesting a possible impairment in the conversion of linoleic acid to arachidonic acid in marasmic children. The ratio of unsaturated fatty acids to saturated fatty acids was markedly elevated in the kwashiorkor group over that of control group, indicating increased fluidity of EM in kwashiorkor. It is suggested that the altered membrane fatty acid composition reflects deranged lipid metabolism and affects the physical and physiological properties of EM and could contribute to changes in the activities of several red blood cell membrane-bound enzymes reported earlier in kwashiorkor children. |
| Databáze: | OpenAIRE |
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