Electrochemical Behaviour and Antioxidant Activity of Some Natural Polyphenols
| Autor: | Roland Zini, Markus Born, Françoise Brée, Bernard Testa, Jean-Paul Tillement, Kurt Hostettmann, Pierre-Alain Carrupt |
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| Rok vydání: | 1996 |
| Předmět: |
ddc:615
Antioxidant biology medicine.medical_treatment Organic Chemistry Serum albumin Biochemistry Redox Catalysis Inorganic Chemistry Lipid peroxidation chemistry.chemical_compound chemistry Chlorogenic acid Polyphenol Drug Discovery medicine biology.protein Organic chemistry Physical and Theoretical Chemistry Mangiferin Quercetin Nuclear chemistry |
| Zdroj: | Helvetica Chimica Acta, Vol. 79, No 4 (1996) pp. 1147-1158 |
| ISSN: | 0018-019X |
| DOI: | 10.1002/hlca.19960790422 |
| Popis: | A number of natural polyphenols (chlorogenic acid (9), cordigol (11), cordigone (12), danthrone (1), 1,5-dihydroxy-3-methoxyxanthone (2), eriosematin (7), flemichin D (8), frutinone A (6), mangiferin (4), quercetin (5), 1,3,6,7-tetrahydroxyxanthone (3) and verbascoside (10)) were investigated for their redox properties using cyclic voltammetry. The antioxidant properties of these compounds were also examined in two models, namely lipid peroxidation in rat synaptosomes and AAPH-mediated oxidation of serum albumin. Compounds with a catechol group (9, 4, 5, 3 and 10) were oxidized below 0.4 V and inhibited lipid peroxidation with IC50 values between 2 and 8 mu M. Compounds having one or more isolated phenolic groups and showing an oxidation potential between 0.45 and 0.8 V (11, 12 and 8) inhibited lipid peroxidation with IC50 between 7 and 9 mu M, except 2 (0.45 V), danthrone (0.96 V) and eriosematin which showed no or modest antioxidant activity. Some of the investigated compounds also protected albumin from oxidation, but no structure-activity relationship was apparent, suggesting that other factors beside redox potential influence this activity |
| Databáze: | OpenAIRE |
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