PPP2R2C as a candidate gene of a temperament and character trait-based endophenotype of ADHD
Autor: | Andreas Reif, Karin Zamzow, Susanne Reichert, Christian Jacob, Thomas Jans, Silke Groß-Lesch, Lena Weißflog, Klaus-Peter Lesch, Stefanie Liedel, Martin J. Herrmann, Thuy Tran Nguyen, Tobias J. Renner |
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Rok vydání: | 2012 |
Předmět: |
Adult
Male Character Candidate gene Endophenotypes media_common.quotation_subject Single-nucleotide polymorphism Comorbidity Polymorphism Single Nucleotide Polymorphism (computer science) mental disorders medicine Humans Genetic Predisposition to Disease Protein Phosphatase 2 Bipolar disorder Allele Child Temperament Nuclear family Genetic Association Studies media_common Psychiatric Status Rating Scales Genetics Mental Disorders General Medicine medicine.disease Psychiatry and Mental health Clinical Psychology Haplotypes Attention Deficit Disorder with Hyperactivity Endophenotype Female Psychology |
Zdroj: | ADHD Attention Deficit and Hyperactivity Disorders. 4:145-152 |
ISSN: | 1866-6647 1866-6116 |
Popis: | There are several lines of evidence that the 4p16 region is a candidate locus of both attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder. None of the harbored candidate genes of this region were hitherto shown to be associated with ADHD despite promising functionality. One of the most promising candidate genes in this region is protein phosphatase 2, regulatory subunit B, gamma (PPP2R2C), which, however, thus far has not been assessed for a potential association with ADHD. A total of 513 in- and outpatients affected with adult ADHD and 536 controls as well as 170 nuclear families with 249 children affected with ADHD were genotyped for 35 SNPs, which tagged the promoter region, the 5' and 3' UTRs, and the exons of the PPP2R2C. Two independent samples provided evidence that the major G allele of rs16838844 increases risk toward ADHD. Allelic variations of PPP2R2C rs16838698 on the other hand might be associated with a variety of personality traits. There is evidence that allelic variation in PPP2R2C may be associated with a variety of personality traits and ADHD per se. Nevertheless, as all those conditions are comorbid, PPP2R2C might reflect a common underlying neurobiological risk factor. |
Databáze: | OpenAIRE |
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