Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts
| Autor: | Michael R. Bristow, Billingham Me, Ginsburg R, Stinson Eb, Cubicciotti Rs, Minobe W, Sageman Ws, Keith G. Lurie, Harrison Dc |
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| Rok vydání: | 1982 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Adrenergic receptor Adenylate kinase Adrenergic Stimulation In Vitro Techniques Tritium Cyclase Fluorides Radioligand Assay Catecholamines Contractile Proteins Internal medicine Receptors Adrenergic beta Humans Medicine Creatine Kinase Heart Failure biology business.industry Myocardium Isoproterenol General Medicine Middle Aged medicine.disease Myocardial Contraction Receptors Adrenergic Hydroxyproline Endocrinology Heart failure Dihydroalprenolol biology.protein Female Creatine kinase medicine.symptom business Adenylyl Cyclases Histamine Muscle contraction |
| Zdroj: | New England Journal of Medicine. 307:205-211 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm198207223070401 |
| Popis: | To identify the role of the myocardial beta-adrenergic pathway in congestive heart failure, we examined beta-adrenergic-receptor density, adenylate cyclase and creatine kinase activities, muscle contraction in vitro, and myocardial contractile protein levels in the left ventricles of failing and normally functioning hearts from cardiac-transplant recipients or prospective donors. Eleven failing left ventricles had a 50 to 56 per cent reduction in beta-receptor density, a 45 per cent reduction in maximal isoproterenol-mediated adenylate cyclase stimulation, and a 54 to 73 per cent reduction in maximal isoproterenol-stimulated muscle contraction, as compared with six normally functioning ventricles (P less than 0.05 for each comparison). In contrast, cytoplasmic creatine kinase activity, adenylate cyclase activities stimulated by fluoride ion and by histamine, histamine-stimulated muscle contraction, and levels of contractile protein were not different in the two groups (P less than 0.05). We conclude that in failing human hearts a decrease in beta-receptor density leads to subsensitivity of the beta-adrenergic pathway and decreased beta-agonist-stimulated muscle contraction. Regulation of beta-adrenergic receptors may be an important variable in cardiac failure. |
| Databáze: | OpenAIRE |
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