Orobanche cernuaLoefling Attenuates Ultraviolet B-mediated Photoaging in Human Dermal Fibroblasts
Autor: | Ying‐ping Wang, Hien T. T. Ngo, Jahyun Bae, Zheng‐yi Qu, Wei Gao, Tae-Hoo Yi, Yu-Shuai Wang, Eunson Hwang |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
MAPK/ERK pathway Antioxidant NF-E2-Related Factor 2 Ultraviolet Rays Photoaging medicine.medical_treatment Radiation-Protective Agents Smad Proteins SMAD Pharmacology Matrix metalloproteinase Biochemistry Collagen Type I 03 medical and health sciences chemistry.chemical_compound Glucosides Phenols Transforming Growth Factor beta medicine Humans RNA Messenger Physical and Theoretical Chemistry Protein Kinase Inhibitors Cells Cultured Skin integumentary system biology Interleukin-6 Orobanche Plant Extracts General Medicine Phenylethanoid Fibroblasts medicine.disease biology.organism_classification Skin Aging Transcription Factor AP-1 Procollagen peptidase 030104 developmental biology chemistry Matrix Metalloproteinase 3 Matrix Metalloproteinase 1 Mitogen-Activated Protein Kinases Reactive Oxygen Species Procollagen Signal Transduction |
Zdroj: | Photochemistry and Photobiology. 94:733-743 |
ISSN: | 0031-8655 |
Popis: | UV radiation is the primary cause of skin photoaging, which results in an increase in matrix metalloproteinases and degradation of collagen. Developing new natural antioxidant as photoprotective agents has become a popular area of research. Orobanche cernua Loefling is a parasitic plant that is rich in phenylethanoid glycosides (PhGs). This study investigated the photoprotective effects of the ethanolic extract of Orobanche cernua Loefling (OC) and its principal component acteoside on UVB-induced photoaging as well as their underlying molecular mechanisms in normal human dermal fibroblasts (NHDFs). Biological testing demonstrated that OC and acteoside possessed significant photoprotective activities, reducing MMP and IL-6 levels while improving type-I procollagen synthesis in UVB-irradiated NHDFs. Further study showed that the protective mechanisms were the improvement of transcription factor Nrf2-mediated antioxidant defensive system, suppression of MAPK/AP-1 and activation of the TGF-β/Smad pathway. Together, our results suggested that OC might be a promising antiphotoaging agent against UV radiation-induced skin damage. |
Databáze: | OpenAIRE |
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