Orobanche cernuaLoefling Attenuates Ultraviolet B-mediated Photoaging in Human Dermal Fibroblasts

Autor: Ying‐ping Wang, Hien T. T. Ngo, Jahyun Bae, Zheng‐yi Qu, Wei Gao, Tae-Hoo Yi, Yu-Shuai Wang, Eunson Hwang
Rok vydání: 2018
Předmět:
0301 basic medicine
MAPK/ERK pathway
Antioxidant
NF-E2-Related Factor 2
Ultraviolet Rays
Photoaging
medicine.medical_treatment
Radiation-Protective Agents
Smad Proteins
SMAD
Pharmacology
Matrix metalloproteinase
Biochemistry
Collagen Type I
03 medical and health sciences
chemistry.chemical_compound
Glucosides
Phenols
Transforming Growth Factor beta
medicine
Humans
RNA
Messenger
Physical and Theoretical Chemistry
Protein Kinase Inhibitors
Cells
Cultured
Skin
integumentary system
biology
Interleukin-6
Orobanche
Plant Extracts
General Medicine
Phenylethanoid
Fibroblasts
medicine.disease
biology.organism_classification
Skin Aging
Transcription Factor AP-1
Procollagen peptidase
030104 developmental biology
chemistry
Matrix Metalloproteinase 3
Matrix Metalloproteinase 1
Mitogen-Activated Protein Kinases
Reactive Oxygen Species
Procollagen
Signal Transduction
Zdroj: Photochemistry and Photobiology. 94:733-743
ISSN: 0031-8655
Popis: UV radiation is the primary cause of skin photoaging, which results in an increase in matrix metalloproteinases and degradation of collagen. Developing new natural antioxidant as photoprotective agents has become a popular area of research. Orobanche cernua Loefling is a parasitic plant that is rich in phenylethanoid glycosides (PhGs). This study investigated the photoprotective effects of the ethanolic extract of Orobanche cernua Loefling (OC) and its principal component acteoside on UVB-induced photoaging as well as their underlying molecular mechanisms in normal human dermal fibroblasts (NHDFs). Biological testing demonstrated that OC and acteoside possessed significant photoprotective activities, reducing MMP and IL-6 levels while improving type-I procollagen synthesis in UVB-irradiated NHDFs. Further study showed that the protective mechanisms were the improvement of transcription factor Nrf2-mediated antioxidant defensive system, suppression of MAPK/AP-1 and activation of the TGF-β/Smad pathway. Together, our results suggested that OC might be a promising antiphotoaging agent against UV radiation-induced skin damage.
Databáze: OpenAIRE
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