Topical 5-Fluorouracil in the Treatment of Cervical Human Papillomavirus Infection
| Autor: | Davila Gw, Shroyer Kr |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
medicine.medical_specialty Administration Topical Biopsy medicine.medical_treatment In situ hybridization Gastroenterology Virus Internal medicine Humans Medicine Dysuria Human papillomavirus Papillomaviridae In Situ Hybridization Gynecology Chemotherapy medicine.diagnostic_test business.industry Papillomavirus Infections Obstetrics and Gynecology female genital diseases and pregnancy complications Tumor Virus Infections Reproductive Medicine Fluorouracil DNA Viral Female Cervical cap medicine.symptom business medicine.drug |
| Zdroj: | Gynecologic and Obstetric Investigation. 41:275-277 |
| ISSN: | 1423-002X 0378-7346 |
| Popis: | Chemosurgical treatment of vaginal/cervical human papillomavirus (HPV) infection with 5-fluorouracil (5-FU) is limited by vulvar pain and dysuria resultant from leakage and vulvar/urethral tissue reaction to the 5-FU. Women with cervical HPV DNA identified by in situ hybridization on colposcopically directed biopsy were treated with topically applied 5% 5-FU cream. A fitted cervical cap was used to restrict exposure to 5-FU. Repeat biopsies and in situ hybridization at least 6 weeks after application failed to detect HPV DNA in 6 of 7 patients. In 1 case, 5-FU treatment was associated with a decreased intensity of detectable HPV DNA. No episodes of vulvar pain or dysuria occurred. 5-FU can be used in the treatment of cervical HPV with minimal side effects when applied utilizing a cervical cap. |
| Databáze: | OpenAIRE |
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