MicroRNA signatures characterize multiple myeloma patients
| Autor: | Justine K. Peeters, Pieter Sonneveld, H B Beverloo, Su Ming Sun, Sonja Zweegman, H. M. Lokhorst, Rowan Kuiper, Sophie L. Corthals, Y. de Knegt, L el Jarari, Mojca Jongen-Lavrencic, Annemiek Broyl, B. van der Holt |
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| Přispěvatelé: | Hematology, Clinical Genetics, Neurosciences, CCA - Disease profiling |
| Rok vydání: | 2011 |
| Předmět: |
Genetics
chemistry.chemical_classification Cancer Research Cell growth Hematology Computational biology Biology medicine.disease Pathogenesis MicroRNAs Oncology chemistry Translational repression Mirna expression Multigene Family microRNA medicine Gene silencing Humans Nucleotide Multiple Myeloma Multiple myeloma |
| Zdroj: | Corthals, S L, Sun, S M, Kuiper, R, de Knegt, Y, Broyl, A, van der Holt, B, Beverloo, HB, Peeters, J K, el Jarari, L, Lokhorst, H M, Zweegman, S, Jongen-Lavrencic, M & Sonneveld, P 2011, ' MicroRNA signatures characterize multiple myeloma patients ', Leukemia, vol. 25, no. 11, pp. 1784-1789 . https://doi.org/10.1038/leu.2011.147 Leukemia, 25(11), 1784-1789. Nature Publishing Group |
| ISSN: | 1476-5551 0887-6924 |
| DOI: | 10.1038/leu.2011.147 |
| Popis: | MicroRNAs (miRNAs) are a class of small non-coding single-stranded RNAs of ~22 nucleotides in length that regulate protein levels by binding to either partially or complete complementary sites in messenger RNAs (mRNAs), leading to translational repression or transcript degradation, respectively. MiRNAs have a role in critical biological processes including cellular growth and differentiation. Recent studies showed that miRNAs have an important role in the pathogenesis of multiple myeloma (MM) and that miRNA signatures are associated with different cytogenetic subtypes. Unsupervised analyses of miRNA expression in MM identified unique clusters, which were not associated with chromosomal abnormalities, while supervised analysis showed a specific miRNA expression pattern for MM subgroups.1, 2, 3 |
| Databáze: | OpenAIRE |
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