Putting Crohn’s on the MAP: Five Common Questions on the Contribution of Mycobacterium avium subspecies paratuberculosis to the Pathophysiology of Crohn’s Disease
Autor: | Michael T. Collins, John Aitken, Harrison Hamblin, Gaurav Agrawal, Thomas J. Borody |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Tuberculosis
Physiology Disease Polymerase Chain Reaction Pathogenesis 03 medical and health sciences 0302 clinical medicine Crohn Disease Paratuberculosis medicine Mycobacteria PCR Animals Humans Crohn's disease Clinical Trials as Topic Invited Review biology business.industry Healthy population Gastroenterology medicine.disease biology.organism_classification Mycobacterium avium subspecies paratuberculosis Pathophysiology Tuberculosis treatment Antibiotic treatment for Crohn's disease Mycobacterium avium subsp. paratuberculosis Mycobacterium avium paratuberculosis 030220 oncology & carcinogenesis Immunology 030211 gastroenterology & hepatology business Mycobacterium |
Zdroj: | Digestive Diseases and Sciences |
ISSN: | 1573-2568 0163-2116 |
Popis: | For decades, Mycobacterium avium subspecies paratuberculosis (MAP) has been linked to the pathogenesis of Crohn's disease. Despite many investigations and research efforts, there remains no clear unifying explanation of its pathogenicity to humans. Proponents argue Crohn's disease shares many identical features with a granulomatous infection in ruminants termed Johne's disease and similarities with ileo-cecal tuberculosis. Both are caused by species within the Mycobacterium genus. Sceptics assert that since MAP is found in individuals diagnosed with Crohn's disease as well as in healthy population controls, any association with CD is coincidental. This view is supported by the uncertain response of patients to antimicrobial therapy. This report aims to address the controversial aspects of this proposition with information and knowledge gathered from several disciplines, including microbiology and veterinary medicine. The authors hope that this discussion will stimulate further research aimed at confirming or refuting the contribution of MAP to the pathogenesis of Crohn's disease and ultimately lead to advanced targeted clinical therapies. |
Databáze: | OpenAIRE |
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