Expression Pattern and Role of Klotho in Human Hair Follicles
| Autor: | Long-Quan Pi, Won-Soo Lee, Xing-Hai Jin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Hair growth Dermatology Biology urologic and male genital diseases Klotho 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Hair cycle Internal medicine Keratin medicine otorhinolaryngologic diseases chemistry.chemical_classification Epidermis (botany) integumentary system Transfection Epithelium female genital diseases and pregnancy complications Endocrinology medicine.anatomical_structure chemistry Apoptosis 030220 oncology & carcinogenesis Human hair growth Original Article sense organs Human hair follicle |
| Zdroj: | Annals of Dermatology |
| ISSN: | 2005-3894 1013-9087 |
| Popis: | Background: Klotho is a newly identified anti-aging protein that plays a pivotal role in regulating ageing. However, whether klotho expresses in human hair follicles (HFs) and whether klotho expression correlates with hair growth have not yet been clearly shown. Objectives: To find the role of Klotho as a regulatory factor for human hair growth Methods: In this study, we examined the expression pattern of klotho in human scalp skin and its role in hair growth. Klotho was expressed in human scalp skin and HF both gene and protein levels. Results: In human scalp skin, prominent klotho expression was observed in the epidermis. Klotho expression in the epidermis was increased with keratinization from basal layer to stratrum coneaum. In human anagen HFs, prominent klotho expression was observed in the epithelium. Klotho expression in the epithelium was increased with keratinization in henle layer and hair cuticle. In human catagen HFs, klotho expression was observed in epithelial strand. Gene transfection of klotho siRNA was markedly inhibited the human hair growth and promoted apoptosis process in organ cultured human follicles. Conclusion: Altogether, these results indicate that klotho might be an important regulatory factor for human hair growth and hair cycle change. |
| Databáze: | OpenAIRE |
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