Perspectives on the Value of Biomarkers in Acute Cardiac Care and Implications for Strategic Management
| Autor: | Mikhael Kossaify, Antoine Ibrahim, Annie Garcia, Antoine Kossaify, Gilles Grollier, Sami Succar, Nicolas Moussallem |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Pharmacology
lcsh:R5-920 Acute coronary syndrome assays business.industry Biochemistry (medical) Atrial fibrillation Disease medicine.disease Bioinformatics point-of-care Heart failure Perspective acute cardiac care cardiovascular system medicine biomarker Molecular Medicine Biomarker (medicine) Tumor necrosis factor alpha Myocardial infarction Endothelial dysfunction lcsh:Medicine (General) business management |
| Zdroj: | Biomarker Insights Biomarker Insights, Vol 8 (2013) |
| ISSN: | 1177-2719 |
| Popis: | Biomarkers in acute cardiac care are gaining increasing interest given their clinical benefits. This study is a review of the major conditions in acute cardiac care, with a focus on biomarkers for diagnostic and prognostic assessment. Through a PubMed search, 110 relevant articles were selected. The most commonly used cardiac biomarkers (cardiac troponin, natriuretic peptides, and C-reactive protein) are presented first, followed by a description of variable acute cardiac conditions with their relevant biomarkers. In addition to the conventional use of natriuretic peptides, cardiac troponin, and C-reactive protein, other biomarkers are outlined in variable critical conditions that may be related to acute cardiac illness. These include ST2 and chromogranin A in acute dyspnea and acute heart failure, matrix metalloproteinase in acute chest pain, heart-type fatty acid binding protein in acute coronary syndrome, CD40 ligand and interleukin-6 in acute myocardial infarction, blood ammonia and lactate in cardiac arrest, as well as tumor necrosis factor-alpha in atrial fibrillation. Endothelial dysfunction, oxidative stress and inflammation are involved in the physiopathology of most cardiac diseases, whether acute or chronic. In summary, natriuretic peptides, cardiac troponin, C-reactive protein are currently the most relevant biomarkers in acute cardiac care. Point-of-care testing and multi-markers use are essential for prompt diagnostic approach and tailored strategic management. |
| Databáze: | OpenAIRE |
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