Prevalence and associated risk factors of coronary artery disease in patients with a zero coronary calcium score
| Autor: | Gonca Erbaş, Fatih Oncu, Mahi Nur Cerit, Mehmet Araç, Zeynep Sezgi Erdal, Koray Kilic, Asife Sahinarslan, Aydan Avdan Aslan, Halit Nahit Şendur, Emetullah Cindil |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Multivariate analysis Cardiovascular risk factors Coronary Artery Disease Coronary Angiography 030218 nuclear medicine & medical imaging Coronary artery disease 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Risk Factors Internal medicine medicine Prevalence Humans Radiology Nuclear Medicine and imaging In patient Male gender Aged business.industry Coronary computed tomography angiography Middle Aged medicine.disease Predictive value Coronary Calcium Score 030220 oncology & carcinogenesis Cardiology Calcium Female business |
| Popis: | Purpose: A zero coronary calcium score (CCS) is not able to provide a definite exclusion for coronary arterydisease (CAD). The goal of this study was to determine the prevalence and associated cardiovascular risk factorsof CAD in patients with zero CCS.Methods: Six hundred thirteen patients with zero CCS referred to coronary calcium score analysis (CCSA) andcoronary computed tomography angiography (CCTA) with suspicion of CAD were included. The descriptive,univariate, and multivariate analyses were used to determine the prevalence and predictors of CAD presence.Results: Among 613 patients, 17 patients (2.7%) have NCCP, and obstructive CAD was found in 3 patients(0.48%). Multivariate analysis revealed that male gender and older age (≥50 years) were significantly associatedwith the presence of noncalcified coronary plaques (NCCP) (p < 0.05). The receiver operating characteristic(ROC) curve analysis showed that the male gender and older age (≥50 years) model had 70.6% sensitivity and84.2% specificity for predicting NCCP.Conclusion: A non-negligible portion of patients with zero CCS had CAD. Male gender and older age (≥50 years)were independently associated with NCCP. Due to the high specificity value (84.2%) and negative predictivevalue (99.0%) of the male gender and older age (≥50 years) model, selective use of CCTA is recommended in<50 years old female patients to avoid unnecessary radiation exposure |
| Databáze: | OpenAIRE |
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