Programming DNA-Based Biomolecular Reaction Networks on Cancer Cell Membranes
| Autor: | Ming Yang, Abeer Eshra, Reem Mokhtar, Daniel Fu, John H. Reif, Tianqi Song, Hieu Bui, Shalin Shah, Sudhanshu Garg |
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| Rok vydání: | 2019 |
| Předmět: |
Aptamer
Cell Synthetic biological circuit 010402 general chemistry 01 natural sciences Biochemistry Catalysis Cell membrane chemistry.chemical_compound Colloid and Surface Chemistry Cell Line Tumor medicine Humans chemistry.chemical_classification Chemistry Biomolecule Cell Membrane DNA General Chemistry Aptamers Nucleotide 0104 chemical sciences ComputingMethodologies_PATTERNRECOGNITION medicine.anatomical_structure Membrane Cancer cell Biological system |
| Zdroj: | Journal of the American Chemical Society. 141:16539-16543 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/jacs.9b05598 |
| Popis: | DNA is a highly programmable biomolecule and has been used to construct biological circuits for different purposes. An important development of DNA circuits is to process the information on receptors on cell membranes. In this Communication, we introduce an architecture to program localized DNA-based biomolecular reaction networks on cancer cell membranes. Based on our architecture, various types of reaction networks have been experimentally demonstrated, from simple linear cascades to reaction networks of complex structures. These localized DNA-based reaction networks can be used for medical applications such as cancer cell detection. Compared to prior work on DNA circuits for evaluating cell membrane receptors, the DNA circuits made by our architecture have several major advantages including simpler design, lower leak, lower cost, and higher signal-to-background ratio. |
| Databáze: | OpenAIRE |
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