Outcome of noncritical COVID-19 patients with early hospitalization and early antiviral treatment outside the ICU

Autor: Murat Akova, Ömrüm Uzun, Sevilay Karahan, Taha Koray Sahin, Serife Gul Oz, Gülçin Telli Dizman, Sehnaz Alp, Arzu Topeli, Ahmet Çağkan İnkaya, Alpaslan Alp, Gulay Sain Guven, Nursel Çalık Başaran, Lale Ozisik, Zahit Tas, Serhat Ünal, Gökhan Metan, Pınar Zarakol, Oğuz Abdullah Uyaroğlu
Rok vydání: 2021
Předmět:
Male
Azithromycin
030204 cardiovascular system & hematology
Single Center
Severity of Illness Index
law.invention
0302 clinical medicine
law
Case fatality rate
Prospective Studies
Prospective cohort study
Aged
80 and over
0303 health sciences
General Medicine
Middle Aged
Early warning score
noncritical illness
Intensive care unit
Anti-Bacterial Agents
Hospitalization
Intensive Care Units
Treatment Outcome
Pyrazines
Drug Therapy
Combination
Female
medicine.drug
Adult
medicine.medical_specialty
hydroxychloroquine
favipiravir
Antiviral Agents
Article
Young Adult
03 medical and health sciences
Early Medical Intervention
Internal medicine
Severity of illness
medicine
Humans
Aged
SARS-CoV-2
030306 microbiology
business.industry
COVID-19
Hydroxychloroquine
Length of Stay
medicine.disease
Amides
COVID-19 Drug Treatment
Pneumonia
Early Warning Score
business
Zdroj: Turkish Journal of Medical Sciences
ISSN: 1303-6165
Popis: Background Despite the COVID-19 pandemic has been going on over 5 months, there is yet to be a standart management policy for all patients including to those mild-to-moderate cases. We evaluated the role of a combined effort of early hospitalization in combination with early antiviral therapy with COVID-19 patients in a tertiary care university hospital. Materials and Methods This was a prospective, observational, single center study on probable/confirmed COVID-19 patients hospitalized in a tertiary care hospital COVID-19 wards between March 20- April 30, 2020. Critically-ill patients requiring intensive care unit (ICU) at the time of admission were excluded. The demographic, laboratory, and clinical data were collected. Results We included 174 consecutive probable/confirmed COVID-19 adult patients hospitalized in the Internal Medicine wards of the University Adult Hospital between March 20 and April 30, 2020. The median age was 45.5 (19-92) years and 91 patients (52.3% ) were male. 120 (69%) were confirmed microbiologically, 41 (23.5%) radiologically diagnosed and, 13 (7.5%) were clinically suspected (negative microbiological and radiological findings compatible with COVID-19). According to WHO definitions, 35 (20.1%) had mild, 107 (61.5%) moderate disease, and 32 (18.4%) had severe pneumonia. Of 130/171 ( 74.3%) showed pneumonia; 80 were typical, 50 indeterminate infiltration for COVID-19. Patients admitted within a median of 3 days (0-14 days) after symptoms appear. The median duration of hospitalization was 4 days (0 - 28 days). In this case series, 13.2% patients were treated with hydroxychloroquine alone, 64.9% with hydroxychloroquine plus azithromycin, and 18.4% with regimens including favipiravir. A total of 15 patients (8.5%) were transferred to the ICU. Four patients died (2.2%). Conclusion In our series, early of 174 patients admitted to the hospital wards for COVID-19, 69% confirmed with PCR and/or antibody test. On the admission nearly one fifth of the patients had severe diseases. 95.4% of the patients received HQ alone or in combination. The overall case fatality rate was 2.2%.
Databáze: OpenAIRE
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