Abnormally high levels of anti-collagen type IV IgG antibodies in the serum of patients with a clinically isolated syndrome correlate with an increased risk of conversion to MS
| Autor: | Anna Marinova, Behidhe Sadarzanska-Terzieva, Plamen Tzvetanov, Vishwajit Hegde, Iveta M. Marinova, Milena Atanassova, Rossen Т. Rousseff, Adelaida Rousseva, Boyko Stamenov, Jasem Y. Al-Hashel, Lubomir Haralanov |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Collagen Type IV Male Risk medicine.medical_specialty Multiple Sclerosis Adolescent Pilot Projects Matrix metalloproteinase Mri studies Gastroenterology Young Adult Internal medicine medicine Humans In patient Collagen type Clinically isolated syndrome biology business.industry Multiple sclerosis General Medicine Middle Aged medicine.disease Prognosis Antibodies Anti-Idiotypic Increased risk Matrix Metalloproteinase 9 Immunology biology.protein Disease Progression Surgery Female Neurology (clinical) Antibody Matrix Metalloproteinase 1 business Demyelinating Diseases |
| Zdroj: | Clinical neurology and neurosurgery. 133 |
| ISSN: | 1872-6968 |
| Popis: | Objective To investigate anti-collagen-type-IV serum antibodies (ACIVAbs) levels in patients with clinically isolated syndrome (CIS), and to determine their predictive value for conversion into multiple sclerosis (MS). Material and Methods Serum levels of IgM and IgG ACIVAbs in 40 untreated patients with CIS (13 male, mean age 34.85±11.4 years, range 16–58 years) were compared to those of 27 gender- and age-matched healthy controls. ACIVAbs were quantified using ELISA. Patients were followed for 5 years by clinical examination and MRI studies. Results Thirty two patients (80%) converted to MS (converted CIS, C-CIS group) while the rest 8 (20%) did not (non-converted CIS, NC-CIS). The C-CIS patients had significantly higher levels of IgG ACIVAb compared to NC-CIS while the IgM levels did not differ between C-CIS and NC-CIS. Conversion to MS occurred in 66% of patients with IgG ACIVAbs levels exceeding the 95th percentile found in controls. IgG ACIVAbs levels correlated positively with the serum levels of matrix metalloproteinases type 9 ( r =0.37; p =0.003) and inversely with those of tissue inhibitor of metalloproteinases type 1 ( r =−0.43; p =0.0008). Conclusion High serum levels of IgG ACIVAbs in patients with CIS correlate strongly with increased risk of conversion to MS. |
| Databáze: | OpenAIRE |
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