Lomefloxacin—Occurrence in the German River Erft, Its Photo-Induced Elimination, and Assessment of Ecotoxicity
| Autor: | Indra Bartels, Anna Nickisch-Hartfiel, Christina Savelsberg, Melanie Voigt, Martin Jaeger, Nina Theiss, Benjamin Hentschel |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Quantitative structure–activity relationship
0208 environmental biotechnology 02 engineering and technology 010501 environmental sciences 01 natural sciences lcsh:TD1-1066 Catalysis Chemical kinetics chemistry.chemical_compound medicine assessment of ecotoxicity MIC lcsh:Environmental technology. Sanitary engineering lcsh:TA170-171 fluoroquinolones Hydrogen peroxide 0105 earth and related environmental sciences QSAR General Engineering AOPs 020801 environmental engineering lcsh:Environmental engineering chemistry high resolution mass spectrometry Environmental chemistry Titanium dioxide Lomefloxacin Degradation (geology) Ecotoxicity IC50 medicine.drug |
| Zdroj: | Clean Technologies Volume 2 Issue 1 Pages 6-90 Clean Technologies, Vol 2, Iss 1, Pp 74-90 (2020) |
| ISSN: | 2571-8797 |
| DOI: | 10.3390/cleantechnol2010006 |
| Popis: | Pharmaceuticals in waters represent a worldwide problem of today. Advanced oxidation processes (AOPs) are being researched for elimination of the ecological hazard. Among the substances, the fluoroquinolone antibiotic lomefloxacin was selected for investigation in this study. Lomefloxacin (LOM) was found in the German river Erft. Near and far ultraviolet (UVA, UVC) radiation were used as AOPs and compared for efficiency depending on pH, water matrix, and catalysts. Chemical kinetics description revealed that UVC at pH 8&ndash 9 led to the fastest degradation of LOM. The catalysts hydrogen peroxide and titanium dioxide had only limited influence on the degradation rate. Seven novel transformation products were structurally identified by high-resolution higher-order mass spectrometry. Ecotoxicity of the novel and known compounds was assessed by quantitative structure-activity relationship (QSAR) analysis. In addition, irradiation time dependent minimal, and half-maximal inhibitory concentrations (MIC, IC50) of LOM solutions were determined and suggested as ecotoxicological hazard indicators. From MIC and kinetic rate constants, the irradiation time required for compound and activity removal could be predicted. |
| Databáze: | OpenAIRE |
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