Structural genomics is the largest contributor of novel structural leverage
| Autor: | Lukasz Jaroszewski, Gaetano T. Montelione, Kouranov Andrei Y, Adam Godzik, Thomas Acton, Christine A. Orengo, Jinfeng Liu, Andras Fiser, John K. Everett, Burkhard Rost, Rajesh Nair, Ta Tsen Soong |
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| Rok vydání: | 2009 |
| Předmět: |
Proteomics
Evolution Computer science Protein Conformation Nuclear Magnetic Resonance 030303 biophysics Structural genomics Protein Data Bank (RCSB PDB) Biophysics Genomics Biochemistry Article 03 medical and health sciences Databases Structural Biology Information and Computing Sciences Genetics Leverage (statistics) Databases Protein Nuclear Magnetic Resonance Biomolecular 030304 developmental biology 0303 health sciences Protein Human Genome Proteins Computational Biology General Medicine Biological Sciences Data science Protein structure determination Structural biology Protein universe UniProt Environmental Sciences Biotechnology Biomolecular |
| Zdroj: | Journal of structural and functional genomics, vol 10, iss 2 Journal of Structural and Functional Genomics |
| Popis: | The Protein Structural Initiative (PSI) at the US National Institutes of Health (NIH) is funding four large-scale centers for structural genomics (SG). These centers systematically target many large families without structural coverage, as well as very large families with inadequate structural coverage. Here, we report a few simple metrics that demonstrate how successfully these efforts optimize structural coverage: while the PSI-2 (2005-now) contributed more than 8% of all structures deposited into the PDB, it contributed over 20% of all novel structures (i.e. structures for protein sequences with no structural representative in the PDB on the date of deposition). The structural coverage of the protein universe represented by today's UniProt (v12.8) has increased linearly from 1992 to 2008; structural genomics has contributed significantly to the maintenance of this growth rate. Success in increasing novel leverage (defined in Liu et al. in Nat Biotechnol 25:849-851, 2007) has resulted from systematic targeting of large families. PSI's per structure contribution to novel leverage was over 4-fold higher than that for non-PSI structural biology efforts during the past 8 years. If the success of the PSI continues, it may just take another approximately15 years to cover most sequences in the current UniProt database. |
| Databáze: | OpenAIRE |
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