Use of omics analytical methods in the study of genetically modified maize varieties tested in 90 days feeding trials

Autor: Hilko van der Voet, Esther J. Kok, Eugenia Barros, Jeroen P. van Dijk, Anna Nadal, Martijn Staats, Arjen Lommen, Jose Luis La Paz, Maria Pla, Maria Corujo, Martijn Slot, Pere Puigdomènech, Marleen M. Voorhuijzen
Přispěvatelé: European Commission
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Proteomics
Novel Foods & Agrochains
BU Toxicologie
BU Contaminanten & Toxines
Biology
Novel Foods & Agroketens
Zea mays
01 natural sciences
One-class model
Analytical Chemistry
Omics data
BU Contaminants & Toxins
0404 agricultural biotechnology
Tandem Mass Spectrometry
GMO (genetically modified organism)
Animals
Metabolomics
BU Toxicology
Novel Foods & Agrochains
Transcriptomics
Chromatography
High Pressure Liquid
VLAG
Risk assessment
2. Zero hunger
Principal Component Analysis
Genetically modified maize
business.industry
010401 analytical chemistry
BU Toxicology
Genomics
04 agricultural and veterinary sciences
General Medicine
Plants
Genetically Modified
Omics
Animal Feed
040401 food science
0104 chemical sciences
Biotechnology
Genetically modified organism
Europe
Biometris
BU Toxicologie
Novel Foods & Agroketens
RNA
Plant
Metabolome
business
Food Science
Zdroj: Food Chemistry 292 (2019)
Food Chemistry, 292, 359-371
Digital.CSIC. Repositorio Institucional del CSIC
instname
ISSN: 0308-8146
Popis: Genetically modified (GM) maize and their non-modified counterparts were compared using MON810 varieties, the only GMO event cultivated in Europe. The differences in grain samples were analysed by omics profiles, including transcriptomics, proteomics and metabolomics. Other cultivated maize varieties were analysed as a reference for the variability that will exist between cultivated varieties. The observed differences between modified and non-modified maize varieties do not exceed typical differences between non-modified varieties. The use of these advanced analytical approaches to analyse novel plant materials as compared to the results from animal feeding trials with whole foods is assessed. No indications were observed for changes in the GM varieties that warrant further investigations. Furthermore, it was shown that such indications will be obtained if maize samples of inferior quality are analysed similarly. Omics data provide detailed analytical information of the plant material, which facilitates a risk assessment procedure of new (GM) plant varieties.
This study was carried out as part of the GRACE project (“GMO Risk Assessment and Communication of Evidence”), financially supported by the 7th Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (FP7), Grant Agreement No. 311957.
Databáze: OpenAIRE
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