Early pancreas transplant improves motor nerve conduction in alloxan-induced diabetic rats
| Autor: | Sandra Alberti, Luiz Antonio de Lima Resende, Amanda Natália Lucchesi, César Tadeu Spadella |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Diabetic neuropathy Time Factors Endocrinology Diabetes and Metabolism medicine.medical_treatment Neural Conduction Motor nerve Pancreas transplantation Diabetes Mellitus Experimental chemistry.chemical_compound Random Allocation Endocrinology Trigeminal Caudal Nucleus Diabetic Neuropathies Internal medicine Diabetes mellitus Alloxan Internal Medicine medicine Animals Glycated Hemoglobin Motor Neurons business.industry General Medicine medicine.disease Sciatic Nerve Compound muscle action potential Rats Transplantation Isogeneic medicine.anatomical_structure chemistry Rats Inbred Lew Hyperglycemia Disease Progression Sciatic nerve Pancreas Transplantation Pancreas business |
| Zdroj: | Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 120(10) |
| ISSN: | 1439-3646 |
| Popis: | The purpose of this study was to assess the temporal relationship between pancreas transplant and the development of electrophysiological changes in the sciatic and caudal nerves of alloxan-induced diabetic rats. Nerve conduction studies were performed in diabetic rats subjected to pancreas transplantation at 4, 12, and 24 weeks after diabetes onset, using non-diabetic and untreated diabetic rats as controls. Nerve conduction data were significantly altered in untreated diabetic control rats up to 48 weeks of follow-up in all time points. Rats subjected to pancreas transplantation up to 4 and 12 weeks after diabetes onset had significantly increased motor nerve conduction velocity with improvement of wave amplitude, distal latency, and temporal dispersion of compound muscle action potential in all follow-up periods (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|