A drug used in traditional medicine, harpagophytum procumbens: no evidence for NSAID-like effect on whole blood eicosanoid production in human
| Autor: | N. Thevenon, M. M. Toubin, J.C. Henry, C. Moussard, D. Alber |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Thromboxane Clinical Biochemistry Prostaglandin Alpha (ethology) Pharmacology law.invention chemistry.chemical_compound law Medicine Humans Whole blood Leukotriene Arachidonate 5-Lipoxygenase biology Traditional medicine business.industry Plant Extracts Anti-Inflammatory Agents Non-Steroidal Cell Biology biology.organism_classification chemistry Pedaliaceae Prostaglandin-Endoperoxide Synthases Eicosanoids lipids (amino acids peptides and proteins) business Phytotherapy Eicosanoid Production |
| Zdroj: | Prostaglandins, leukotrienes, and essential fatty acids. 46(4) |
| ISSN: | 0952-3278 |
| Popis: | Devil's Claw (Harpagophytum procumbens), an herbal product being marketed in Canada and in Europe as a home remedy for the relief of arthritic disease, was investigated in healthy humans on eicosanoid production during spontaneously blood clotting. Volunteers took H. procumbens (daily 4 capsules of 500 mg powder containing 3% of total glucoiridoids) for a period of 21 days. The following are the results (mean (SEM)): before H. procumbens intake, prostaglandin (PG)E2 (ng/ml serum): 2.1 (0.4) (n = 25), thromboxane (TX)B2: 147 (27) (n = 25), 6-keto-PGF1 alpha: 4.4 (0.7) (n = 13), leukotriene (LT)B4: 3.4 (0.4) (n = 25); after intake: PGE2: 3.2 (0.6), TXB2: 143 (24), 6-keto-PGF1 alpha: 4.2 (0.9), LTB4: 3.8 (0.6). Each subject serving as her own control, no statistically significant differences were observed between before and after H. procumbens intake. These results indicate that Devil's Claw lacks, at least in healthy humans and under the selected conditions, the biochemical effects on arachidonic acid metabolism of antiarthritic drugs of the non-steroidal antiinflammatory type. |
| Databáze: | OpenAIRE |
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