Changing Patterns of Infections in Patients with Multiple Myeloma
| Autor: | Peter C. Appelbaum, Baku S. Shaikh, Robert M. Lombard, Michael S. Bentz |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Haemophilus Infections Urinary system Leukocyte Count Sepsis Internal medicine medicine Humans Gram-negative rods In patient Respiratory Tract Infections Multiple myeloma Aged Cross Infection Gram-Negative Aerobic Bacteria business.industry Enterobacteriaceae Infections Bacterial Infections General Medicine Middle Aged medicine.disease medicine.anatomical_structure Oncology Urinary Tract Infections Immunology Female Multiple Myeloma business Respiratory tract |
| Zdroj: | Oncology. 39:78-82 |
| ISSN: | 1423-0232 0030-2414 |
| DOI: | 10.1159/000225611 |
| Popis: | A total of 59 infections were encountered in 29/46 patients with multiple myeloma (MM). Most infections arose in the urinary tract (31%), respiratory tract (29%), followed by blood (12%), oropharynx (12%), skin and soft tissue (7%). Gram-negative bacilli were identified in 51% of infections, most common being Enterobacteriaceae and Haemophilus influenzae. Gram-positive organisms were responsible for 7% of infections. 24% of patients with urinary tract infections had signs of cord compression Absolute lymphopenia was common, and was seen in 65% of patients with urinary infections, 75% of respiratory infections, and 86% of septicemic patients. In contrast, granulocytopenia was mainly observed in patients with septicemia (71%), followed by those with respiratory infections (31%). All patients were on cytotoxic chemotherapy, and most were hypoglobulinemic. About one third of septicemias, and one half of urinary and respiratory infections, respectively, were hospital-acquired. Results indicate that the current pattern of infections in MM seems to favor gram-negative organisms. The role of predisposing factors in the pathogenesis of infections in these patients is discussed. |
| Databáze: | OpenAIRE |
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