Protection of Encapsulated Human Islets Implanted Without Immunosuppression in Patients With Type I or Type II Diabetes and in Nondiabetic Control Subjects
| Autor: | Maha F Ansara, Paul E. Lacy, Orion D. Hegre, David W. Scharp, Paul Latta, Frank T. Gentile, Barbara Olack, Carol J. Swanson, Karen Flavin, Doherty Edward J |
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| Rok vydání: | 1994 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Biocompatibility Cell Survival Endocrinology Diabetes and Metabolism medicine.medical_treatment Islets of Langerhans Transplantation Biocompatible Materials Type ii diabetes Islets of Langerhans Immune system Theophylline Internal medicine Diabetes mellitus Insulin Secretion Internal Medicine medicine Humans Insulin Immunosuppression Therapy geography geography.geographical_feature_category business.industry Membranes Artificial Immunosuppression Islet medicine.disease In vitro Diabetes Mellitus Type 1 Glucose Endocrinology Diabetes Mellitus Type 2 business |
| Zdroj: | Diabetes. 43:1167-1170 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/diab.43.9.1167 |
| Popis: | Human islets were macroencapsulated in permselective hollow fiber membrane devices and successfully allotransplanted subcutaneously with > 90% viability after 2 weeks in situ. Recipients were patients with type I or type II diabetes and normal control subjects; none was immunosuppressed. Between 150 and 200 islet equivalents were implanted in each of the nine patients. No adverse patient complications were observed. Biocompatibility of devices was excellent. Insulin-positive β-cells were confirmed in encapsulated islets recovered from the implanted devices in all patient populations including the type I diabetic patients. Glucose-stimulated insulin release could be demonstrated in vitro from recovered islets. These data demonstrate that macroencapsulated human islets can survive at the subcutaneous site and that permselective membranes can be designed to protect against both allogeneic immune responses as well as the autoimmune component of type I diabetes. |
| Databáze: | OpenAIRE |
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