Cyclic angiotensin-(1-7) contributes to rehabilitation of animal performance in a rat model of cerebral stroke
| Autor: | Aharon Levy, Anneke Kuipers, Gert N. Moll, Rick Franklin, Michael Krakovsky |
|---|---|
| Přispěvatelé: | Molecular Genetics |
| Rok vydání: | 2020 |
| Předmět: |
Male
Endothelium Physiology medicine.medical_treatment Rat model Pulmonary disease 030209 endocrinology & metabolism Cerebral stroke Peptides Cyclic Biochemistry Rats Sprague-Dawley 03 medical and health sciences Cellular and Molecular Neuroscience Subcutaneous injection 0302 clinical medicine Endocrinology medicine Animals Kidney Rehabilitation Angiotensin 1 business.industry Stroke Rehabilitation Recovery of Function Peptide Fragments Rats Stroke Disease Models Animal medicine.anatomical_structure Anesthesia Angiotensin I business 030217 neurology & neurosurgery |
| Zdroj: | Peptides, 123:170193. ELSEVIER SCIENCE INC |
| ISSN: | 0196-9781 |
| Popis: | Peptidase-resistant, lanthionine-stabilized angiotensin-(1-7), termed cAng-(1-7), has shown therapeutic efficacy in animal models of cardiovascular, metabolic, kidney and pulmonary disease. Goal of the present study was testing the capacity of subcutaneously administered cAng-(1-7) to induce rehabilitation of animal performance in the transient middle cerebral artery occlusion rat model of cerebral stroke. 24 h after ischemic stroke induction, cAng-(1-7) was administered for 28 days at a dose of 500 μg/kg/day, either daily via subcutaneous injection or continuously via an alzet pump. Both ways of administration of cAng-(1-7) were equally effective. Measurements were continued until day 50. Compared to vehicle, cAng-(1-7) clearly demonstrated significantly increased capillary density (p < 0.01) in the affected hemisphere and improved motor and somatosensory functioning. The modified neurological severity score (p < 0.001 at days 15 and 50), stepping test (p < 0.001 at days 36–50), forelimb placement test (p < 0.001 at day 50), body swing test (p < 0.001 at days 43 and 50) all demonstrated that cAng-(1-7) caused significantly improved animal performance. Taken together the data convincingly indicate rehabilitating capacity of subcutaneously injected cAng-(1-7) in cerebral ischemic stroke. |
| Databáze: | OpenAIRE |
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