Backbone distortions in lactam‐bridged helical peptides

Autor:	Ali Moazzam, Vesna Stanojlovic, Arthur Hinterholzer, Christoph Holzner, Cornelia Roschger, Andreas Zierer, Markus Wiederstein, Mario Schubert, Chiara Cabrele
Rok vydání:	2022
Předmět:	Pharmacology Lactams Protein Conformation Circular Dichroism Organic Chemistry Valine General Medicine Peptides Cyclic Biochemistry Protein Structure Secondary Structural Biology Drug Discovery Tyrosine Molecular Medicine Isoleucine Peptides Molecular Biology
Zdroj:	Journal of Peptide Science. 28
ISSN:	1099-1387 1075-2617
Popis:	Side-chain-to-side-chain cyclization is frequently used to stabilize the α-helical conformation of short peptides. In a previous study, we incorporated a lactam bridge between the side chains of Lys-i and Asp-i+4 in the nonapeptide 1Y, cyclo-(2,6)-(Ac-VKRLQDLQY-NH
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a59094f4933fb35d9ed25b63d1da5b https://doi.org/10.1002/psc.3400 Zobrazit plný text záznamu Plný text