Shortening versus isometric contractions in isolated human failing and non-failing left ventricular myocardium: dependency of external work and force on muscle length, heart rate and inotropic stimulation
| Autor: | H. Just, H. Posival, Stephan Schmidt-Schweda, H Schulte-Baukloh, S Wiessner, J Lüdemann, Burkert Pieske, Ch. Holubarsch, Th Ruf |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Cardiomyopathy Dilated Inotrope medicine.medical_specialty Cardiotonic Agents Adolescent Physiology Cardiomyopathy Hemodynamics Isometric exercise Ventricular Function Left Ouabain Heart Rate Physiology (medical) Internal medicine Heart rate medicine Humans Aged Thiadiazines business.industry Isoproterenol Middle Aged medicine.disease Myocardial Contraction Stimulation Chemical Circulatory system Quinolines Cardiology Regression Analysis Calcium medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug Muscle contraction |
| Zdroj: | Cardiovascular Research. 37:46-57 |
| ISSN: | 0008-6363 |
| DOI: | 10.1016/s0008-6363(97)00215-0 |
| Popis: | Background: For reasons of simplicity, studies on isolated human myocardium have been conducted using exclusively isometric contractions, although positive inotropic interventions may differently influence force development, extent of shortening and myocardial work performance. We investigated human left ventricular failing and non-failing preparations comparing isometric versus isotonic, i.e., shortening contractions. Results: (1) When muscle length is increased from 90% to 100% l max, peak developed force increases by 36% and 43% ( p |
| Databáze: | OpenAIRE |
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